A new play that is out:
Spare Parts
A pointed play explores what happens when scientists sell out to help a billionaire live forever
Review: A billionaire’s quest for immortality in ‘Spare Parts’ at NYC’s Theatre Row - DC Theater Arts
Website for Play: https://www.sparepartsplay.com
Review in “Science” magazine / journal.
Wow… among other things… the article says…“dubious advice from Peter Attia…” Ouch!
Looks like a fun play!
Planetary terminal infectious diseases.
Looksmaxxers providing health advice … great for humor, just don’t follow it.
https://x.com/yonann/status/2046914663640973539?s=20
Increlex (Mecasermin) is a recombinant human insulin-like growth factor-1 (rhIGF-1) indicated for the long-term treatment of growth failure in children. It is specifically designed for patients with Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD) or those with growth hormone (GH) gene deletion who have developed neutralizing antibodies to GH.
Clinical Details
- Mechanism of Action: Increlex acts as a replacement for endogenous IGF-1, which is the principal mediator of growth hormone’s effects on bone and tissue growth. In patients with SPIGFD, the body produces GH but cannot effectively generate IGF-1.
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Indications: * Pediatric patients (≥2 years old) with height and basal IGF-1 standard deviation (SD) scores \le -3.0.
- Growth hormone gene deletion with neutralizing antibodies to GH.
- Contraindications: Active or suspected neoplasia, closed epiphyses (growth plates), or known hypersensitivity to mecasermin.
- Administration: Subcutaneous injection. It is critical to administer Increlex shortly before or after (±20 minutes) a meal or snack due to its potent insulin-like hypoglycemic effects.
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Dosage: * Starting dose: 0.04 to 0.08 mg/kg twice daily.
- Maximum dose: 0.12 mg/kg twice daily.
Pricing and Availability
Increlex is a high-cost specialty pharmaceutical. As of early 2026, pricing remains substantial, reflecting its orphan drug status.
| Component | Estimated Cost (USD) | Notes |
|---|---|---|
| Wholesale Acquisition Cost (WAC) | ~$5,000 – $6,500 per vial | Per 40 mg/4 mL (10 mg/mL) multi-dose vial. |
| Price per mg | ~$125 – $160 | Costs vary by pharmacy and payer contract. |
| Annual Treatment Cost | $50,000 – $150,000+ | Highly dependent on the child’s weight and dosage titration. |
Note: Most patients access this drug through private insurance or Medicaid, which typically requires strict Prior Authorization ¶. Payers generally require proof of SPIGFD (Height SD $\le -3.0$) and confirmation that growth hormone deficiency has been ruled out via provocative testing.
Critical Safety Information & Side Effects
- Hypoglycemia: The most common and serious acute risk. Patients must have adequate caloric intake around the time of injection.
- Lymphoid Hypertrophy: Common enlargement of tonsils and adenoids; periodic examinations are required to monitor for sleep apnea or hearing loss.
- Intracranial Hypertension: Some patients may develop increased pressure in the head, manifesting as headaches, nausea, or papilledema.
- Slipped Capital Femoral Epiphysis (SCFE): Rapid growth can lead to hip or knee pain; any limp should be evaluated immediately.
- Malignancy Risk: There have been post-marketing reports of both benign and malignant neoplasia in children treated with Increlex.
Sources:
I had Claude build a health tracker so I can more accurately track how I feel when I change various interventions.
I had him go through my posts to figure out when I started taking certain things….
I see he found a particular comment I made 
Its good Claude doesn’t hold a grudge 
When they eventually come for us, I’m gonna be one of the first to go.
Thoughts of the day.
“The longest sentence you can form with two words is ‘I do.’”
― H.L. Mencken
“Men are like banks. The more money they have, the more interest they get.”
Crap! Today I learned that the CDC considers me in the oldest old category. "This is especially common in the “oldest old” (those aged 85 and older)" 
• New study suggests alterations in gut microbiota, gene expression and metabolism, with some effects persisting in offspring
– SCMP China Science
I had to look up “nonce” …
British Slang: A term used for a child molester or sex offender.
