Japanese scientists develop vaccine to eliminate senescent cells

A Japanese research team said it developed a vaccine to remove so-called zombie cells that accumulate with age and damage nearby cells, causing aging-related diseases including arterial stiffening.

“We can expect that (the vaccine) will be applied to the treatment of arterial stiffening, diabetes and other aging-related diseases,” Minamino said.

When the team administered the vaccine to mice with arterial stiffening, many accumulated senescent cells were removed and areas affected by the disease shrank. When administered to aged mice, their frailty progression was slower than that of unvaccinated mice, according to the team.

Research Paper (blocked by paywall):

https://www.nature.com/articles/s43587-021-00151-2

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I’m really curious to know if clearing senescent cells could help to reverse calcified arterial plaque over time, or at least if it could safely reverse non-calcified/soft plaque without causing it to rupture. This would be revolutionary in the prevention of heart attack/stroke in vulnerable populations.