It’s time to admit that genes are not the blueprint for life (Nature)

The view of biology often presented to the public is oversimplified and out of date. Scientists must set the record straight, argues a new book.

How Life Works: A User’s Guide to the New Biology Philip Ball Pan Macmillan (2024)

For too long, scientists have been content in espousing the lazy metaphor of living systems operating simply like machines, says science writer Philip Ball in How Life Works. Yet, it’s important to be open about the complexity of biology — including what we don’t know — because public understanding affects policy, health care and trust in science. “So long as we insist that cells are computers and genes are their code,” writes Ball, life might as well be “sprinkled with invisible magic”. But, reality “is far more interesting and wonderful”, as he explains in this must-read user’s guide for biologists and non-biologists alike.

When the human genome was sequenced in 2001, many thought that it would prove to be an ‘instruction manual’ for life. But the genome turned out to be no blueprint. In fact, most genes don’t have a pre-set function that can be determined from their DNA sequence.

Instead, genes’ activity — whether they are expressed or not, for instance, or the length of protein that they encode — depends on myriad external factors, from the diet to the environment in which the organism develops. And each trait can be influenced by many genes.

Full Article:
https://www.nature.com/articles/d41586-024-00327-x

Other Reviews

Buy on Amazon:

https://www.amazon.com/How-Life-Works-Users-Biology/dp/0226826686/

9 Likes

I have bought this and started reading it. I find it quite a good book and well worth getting.

I would say, however, “It’s time to admit that genes are not the blueprint for life” is not really an accurate title to describe the book. It does explain the complexity of cellular biochemistry and that there are things beyond genes that can be inherited.

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I just uploaded it to my Kindle. Hope it is a good read.