Is using a 6-month overdue rapamycin safe?

#1

Is using a 6-month overdue rapamycin safe?

#2

yes, no problems…

https://www.ualberta.ca/en/folio/2018/10/can-i-still-use-prescription-drugs-after-they-expire.html

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#3

I depends where it has been? Drugs like rapamycin maintain themselves best at lower temperatures, and with no exposure to humidity and especially light. On a quick search, sirolimus samples stored at 30 degrees C, but in light for a week had concentration loss of 5%.
So stored at modest/cool temperature always, no sunlight/humidity … I’d have no worries about 6 months or even a year post dates … but if transported in 140 degree F heat, exposed to the environment - they might not be that great on arrival.

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#4

Potency may be an issue, but there is no reason to believe that they would be at all harmful is there?

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#5

I agree, not so worried about toxicity - although I don’t know what becomes of the rapamycin that isn’t active, as to what it degrades to. It would be more of an efficacy issue.

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#6

I concur. For me, as long as it somehow doesn’t degrade into something metabolically toxic, I’d finish it off.

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