Like would you pee more on 500 than 300 mg canagliflozin?
Do you pee out only a little more on 300 vs 150?
the maximum value measured by rupa labs is 2100 mg/dl, but this is actually very small (if you pee out 1L per day, that translates to 21g, or 84 cal per day). I measured that, but I’m still at a loss of how high it could go
Thought about buying glucose test strips and measuring volume of pee in comparison to the glucose content?
I take Empagliflozin 25mg which is equavlient 300 of canagliflozin for 2 yrs. It is not the volume of urine, but the amount of glucose removed in the kidneys. Appx 35%. My urinalysis shows glucose levels off the charts. I also take acarbose 100mg with meals. Here is a study comparing sglt2 inhibitors with Empagliflozin recommended, also cheaper
“%. My urinalysis shows glucose levels off the charts”
how much?
3rd day after end of canagliflozin( tho 2.5 days after more accurate): 733.0 mg/dl sugar in urine, or 29 calories per liter
3.47 liters of blood in someone of my body size
that’s 3391.5 mg, or 3.4 g of glucose in my blood at any time, assuming 95 mg/dl average BG…
And I’m peeing over 21g/day of it on canagliflozin, which means quite a number of glucose exchanges.
Small body size also means worse glucose spikes from the same amount of fruit calories…
well I had a test sample run at 5763.13 mg/dl glucose…
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Short answer: A bit, for specific solutes—but it’s not a “detox” drug.
What canagliflozin clearly increases in urine
- Glucose → big increase (that’s its job), with a brief bump in urine volume early on. (NCBI, PMC, Frontiers, American Heart Association Journals)
- Uric acid → yes (uricosuric effect). SGLT2 inhibitors, including canagliflozin, lower serum uric acid by increasing fractional excretion; the strength of uricosuria tracks with the degree of glycosuria. Mechanisms involve changes in proximal tubular urate handling (URAT1/GLUT9). (PMC, Physiology Journals, JACC)
Protein-bound “uremic toxins” (indoxyl sulfate, p-cresyl sulfate, etc.)
- Evidence in humans is limited/uncertain about increasing their urinary clearance. Reviews call this an open question. (PMC)
- In animal/CKD models, canagliflozin lowered plasma levels of gut-derived toxins and shifted the microbiome; this likely reflects reduced production more than proven increases in renal excretion. (Some studies measured urinary IS/PCS, but the consistent human signal for “more urinary toxin dumping” isn’t there yet.) (Physiology Journals, PMC)
Other notes
- Natriuresis/osmotic diuresis is transient; after the first days, urine volume tends toward baseline despite continued glucosuria. So any nonspecific “flushing” effect is modest and short-lived. (Frontiers, PMC)
- Albuminuria generally decreases on SGLT2 inhibitors (good for kidneys)—so not “more protein toxins out.” (This is well-shown across trials, though not the focus of your question.) (Nature)
Bottom line
- Yes, on the margin: more uric acid (and of course glucose) in the urine.
- For broad “toxins,” especially protein-bound uremic toxins, no solid human evidence that canagliflozin meaningfully boosts urinary elimination; benefits there seem to come more from lower generation and kidney protection than from “peeing out more toxins.” (PMC, Physiology Journals)
If you want, tell me which “toxins” you care about (uric acid, IS/PCS, oxalate, heavy metals, BPA, etc.), and I’ll zero in on what data exists for each.
That’s impressive! Can you approximate the total number of grams of glucose you are peeing out every day?
Last year you mentioned 21g per day, which is 84kcal. Not a super high amount, but not nothing either.
Id have to estimate how much liters per day
Last year’s measurements were capped bc rupa labs only had a max level of glucose above which the measurement saturated