that succinate dehydrogenase (SDH) is differentially affected by aging in neurons and astrocytes. SDH is a mitochondrial energy nexus and serves as complex II of the mitochondrial electron transport chain (ETC). SDH connects the tricarboxylic acid cycle (TCA) to the ETC. This result indicates that pre- and post-SDH enzymes of TCA (fumarase and succinate CoA ligase) display opposite changes in aged neurons and astrocytes. SDH itself decreases more in aged neurons than in aged astrocytes. In neurons, aging reduces both succinate CoA ligase and SDH, while increasing fumarase. Unlike in neurons, succinate CoA ligase levels rise in astrocytes during aging. SDH decreases slightly while fumarase levels decline more.
One of Nick Land’s Transformer books also discusses it