Is Rapamycin Dead? (Kaeberlein)

#61

That sounds like a good strategy. Where di you hear about once a week for 3 months and 1 month off?

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#62

Great to hear it has helped you. I also like RAPA. Out of curiosity have you been doing any of the supposed synergetic meds (.ie Metformin, Acarbose, SGLTiā€™s or any of lipid lowering drugs) with Rapa, or just Rapa alone?

#63

I donā€™t think itā€™s a matter of hearing it anywhere, and some docā€™s might have recommended it that way but it is mostly trial and error. Manny people do different versions, i.e. I used to do four weeks on, and two weeks off (but donā€™t ask me the reason LOL). now Iā€™ve stopped as Iā€™m doing the TRIIM. I intend to do only 6 months of TRIIM because the HGH tends to make my head look bigger (and i donā€™t like that) lol. Otherwise, Iā€™d probably done at least one year. Plus, I hate the fact that I canā€™t do RAPA (when on TRIIM) since I also have a positive attitude toward RAPA.

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#64

Past 6 monthsā€¦ 3 months rapamycin 6 mg weekly.

Then no rapamycinā€¦ 1 month daily HGH 3.5 iu. Dr. Greg Fahy felt rapamycin prevents the thymus from finishing the T-cellsā€¦ so, a break is needed.

The month break in rapamycin gives the thymus an opportunity to release new T-cells.

Then, back to rapamycin 6 mg weekly.

From my CT scan in February (after 3 months no rapamycin). ā€¦ I know my thymus is adipose/fat freeā€¦ and a healthy size.

Seems to be working great :+1:

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#65

Common marmoset ~93ā€“95% (Close primate cousin)
Domestic pig~85ā€“90%

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#66

Thatā€™s really interesting Jason. How long have you been on HGH following Fahyā€™s advice?

My understanding of the thymus is that it largely turns into fat by our mid 60s. Regular exercise is consistently associated with a larger, more functional thymus in older adults.

Weā€™d all like the benefits of a healthy Thymus, Increased naive T cells, Better T-cell diversity, Reduced chronic inflammation and Less fatty replacement of the thymus.

It would be great to be able to preserve a functional Thymus.

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#67

Yes, the Thymus is very important to health and longevity. I started daily injections 3.5 iu of HGH in February 2025. I know my HGH stock was good due to my IGF blood test. Prior to HGH my IGF-1 level was 195. Good for a male almost 67 years. After HGH for 6 months my level My IGF-1 scoare was 450.

At one year use - February 2026 I had a CT scan of my thymus - large, healthy and fat free. See CT scan large image and a detail shot.

Now my protocal is 3 months on rapamycin. Then a break and one month daily injection of 3.5 iu HGH. Followed by 3 months rapamycin - than break for HGH one month.

Thymus is top center light grey pointy gland. Large with no fat - seen as white and opaque.

Tap to see

CT Scan Jason February 16, 2026.pdf (2.5 MB)

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