[# Prodrome BDMC (GTA)™
Curcuminoid Supplement](Prodrome | Prodrome BDMC (GTA)™)
Does it help reduce NeuroAge more than other things do?
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Have you compared to Theracurmin?
Supposed be more than a order of magnitude more bioavailable that normal ones
Peter Attia has often feature it as one his few favorite supplements
It’s not cheap, but they do seems have some clinical evidence:
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That’s super interesting; thanks for sharing @Neo.
Curcumin is a mild MAO-A and MAO-B inhibitor (source). Given Theracurmin’s higher bioavailability, does it mean it’s a potent MAO inhibitor? If so, is there a risk of serotonin syndrome? What about a hypertensive crisis when eating high-tyramine foods?
And can Theracurmin be taken together with other MAO-B inhibitors, such as selegiline? (poke @Steve_Combi ).
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I’d guess it would depend on dose 
I take amlodipine (10mg) at night and take selegiline(1.25mg) in the morning, both low dose and there is a contraindication for these 2. I don’t notice any issues.
There are a LOT of contra’s for selegiline. But we are not anywhere near the dose levels used in treating Parkinsons - 10mg to 60mg per day.
https://www.drugs.com/drug-interactions/selegiline-index.html
The preceding drug and food contraindications are dependent on selegiline dose and route, and hence are not necessarily absolute contraindications.[4][6][5][7][9] While high oral doses of selegiline (≥20 mg/day) can cause such interactions, oral doses within the approved clinical range (≤10 mg/day) appear to have little to no risk of these interactions
I also take amlodipine and selegiline, but the interaction is moderate. It’s nothing in practice.
The dose for Parkinson’s disease is usually 5 mg. It’s never 60 mg. At most PD patients take 10 mg (5 mg twice a day).
What I wonder is: what’s the MAO inhibition potency of the typical Theracurmin dose (90 mg)? Is it equivalent to more or less than 1.25 mg of selegiline? If it’s less than 1.25 mg then your total “MAO inhibition” is equivalent to less than 2.5 mg selegiline, which is fine. But what if it’s more than that? Then you run into risk of serotonin syndrome and hypertension crisis.
For now I’m taking “normal” curcumin (372 mg) so there’s no risk with selegiline. I considered switching to Theracurmin but I’m not sure now… Where could I find the information?
Curcumin does have MAO inhibition potential. I’d guess that since you have no adverse reaction it’s weak. Also 1.25mg selegiline is pretty weak in that area as well.
As far as finding a definitive answer on Theracumin, my guess is that will be hard to find, if if there is any hard data on that at all.
Yes curcumin MAO inhibition is negligible.
For Theracurmin I asked a Parkinson’s disease researcher. I’ll let you know…
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