Metformin is also synergistic with Rapamycin. The two drugs enhance each others benefits while minimizing each others detriments.
Researchers have revealed that the moderate weight loss associated with metformin is due to an “anti-hunger” molecule, known as lac-phe, which is also produced after vigorous exercise.
So do we have a chemist here? Lac-phe doesn’t sound complicated. Could you make it and take it orally? Looks to me like it’s only injected.
Already manufactured and sold on the market.
So, does it work? I don’t hear much about everyone running to their doctor to get Metformin for weight loss.
I have not lost any weight on Metformin. However, I haven’t gained much weight either.
You’re unusual, it seems:
In a long-term study involving over 3,000 people, the average weight loss for participants who took metformin was 5.5 pounds. About one-third of those who took metformin lost at least 5% of their body weight after a year. And the longer they took it (up to 15 years), the better the results, with an average long-term loss of 6.2% of body weight
Source: Can Metformin Help with Weight Loss?.
It is typical but annoying that at lest standard deviations are not provided on these means and, as far as I can see, the referenced research is behind a paywall. A mean of 5.5 with a SD of 4.5 likely reflects an entirely different dynamic than a mean of 5.5 and a SD of 1.0.