Bryan Johnson says it accelerates it
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After approximately a year and a half of investigation, we are happy to announce new research from Big Bold Health and TruDiagnostic. Thank you to all authors who were imperative in generating the data, formulating the narrative, and pushing the project to publication: Austin Perlmutter, MD, Jeffrey Bland, PHD, Arti Chandra, Sonia M., Ryan Smith, and Tavis Mendez.
Our latest research on Tartary buckwheat, a superfood rich in polyphenols, dives deep into how nutrition influences aging and immunity at the molecular level. Using epigenetic testing, we uncovered exciting personalized insights—but the real breakthrough lies in its alignment with key biological pathways linked to health and longevity.
What We Found:
Aging Isn’t One-Size-Fits-All: While some participants saw slower biological aging (via PCPhenoAge), others showed no change, underscoring the potential for personalized dietary interventions.
Immune Modulation: Changes in immune cells like CD4+ and CD8+ memory cells highlight its impact on immune aging—but these effects varied among individuals.Critical Pathways Unlocked: The most exciting discovery was the strong connection to:
Ceramide Kinase Activity: A 22x enrichment in CpG methylation related to this pathway—crucial in inflammation and cellular senescence. Polyphenols like those in Tartary buckwheat may modulate ceramide levels, aligning with prior research linking these pathways to longevity and reduced inflammation.COP9 Signalosome: This pathway, enriched 6.7x, plays a role in immune regulation, neuroinflammation, and cellular aging. Tartary buckwheat may act on COP9 to promote resilience and healthy cellular function.
Why It Matters:
These findings align closely with previous research, reinforcing the role of these pathways in longevity and immune regulation. What’s more, epigenetic testing allows us to uncover personalized responses, showing whether foods like Tartary buckwheat are beneficial for
youWhat’s Next?
Expand studies to understand why responses vary among individuals.
Investigate how microbiomes and lifestyle factors modulate these effects.
Use advanced profiling to target immune and aging-related pathways further.Takeaway: With precision epigenetics, we’re entering a future where foods like Tartary buckwheat support health and do so in a way tailored to your biology. Ceramide kinase activity, COP9, and other pathways are key to unlocking personalized longevity solutions.