If you read Preston Estep’s mindspan, this is a good thing
1 Like
The list of all compounds tested by the ITP and in progress is on the ITP website at Supported Interventions | National Institute on Aging . To date, six compounds have shown significant extension of lifespan:
Aspirin – males only (Strong et al., 2008 );
Preston "Pete" Wayne Estep III is an American biologist and science and technology advocate. He is a graduate of Cornell University, where he did neuroscience research, and he earned a Ph.D. in Genetics from Harvard University. He did his doctoral research in the laboratory of genomics pioneer Professor George M. Church at Harvard Medical School.
Estep is an inventor of several technologies including DNA chip-based readout of transposon-based selections and universal DNA protein-binding microar...
1 Like
I thought there was recent evidence showing long term use has a risk of heart failure.
J0hn
January 17, 2024, 9:55am
#4
Anemia may not be a bad thing as far as aging is concerned ?
Yeah, well, here’s the thing: If you are on rapamycin your iron levels should be lower. Mine certainly are.
"In turn, mTOR also exerts control over iron metabolism, and the inhibition of mTOR activity by rapamycin leads to inhibition of iron accumulation via the iron-regulating hormone hepcidin [10]. Transplant patients taking sirolimus (rapamycin) often develop a microcytic anemia, which has been linked to sirolimus-induced iron deficiency
Apologies if I haven’t done the link properly
2 Likes
MJT
January 17, 2024, 4:34pm
#5
The amount of evidence showing aspirin reduces risk of cancer is pretty substantial.
JuanDaw
January 17, 2024, 5:36pm
#6
https://www.acpjournals.org/doi/abs/10.7326/M23-0675?journalCode=aim
Anemia incidence in the aspirin and placebo groups was 51.2 events and 42.9 events per 1000 person-years, respectively (hazard ratio, 1.20 [95% CI, 1.12 to 1.29]).
Eight more incidences of anemia per 1000 person/years.
1 Like
I don’t like it because it is a Cox-1 inhibitor. It therefore reduces melatonin levels and disrupts sleep.
Previous studies have demonstrated that some nonsteroidal anti-inflammatory drugs (NSAIDs), specifically aspirin and indomethacin, have acute negative effects on sleep in humans and animals. Whether this finding can be replicated and extended to...
2 Likes