Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation

#1

https://www.nature.com/articles/s41586-022-05380-y

When mice are fed inulin fiber, their intestines and lungs develop hallmark features of type 2 inflammation, including elevated levels of IL‑33 (an alarmin cytokine), activation of type 2 innate lymphoid cells (ILC2s), and eosinophilia. Moreover, in models of allergic disease (such as house dust mite‑induced asthma) or parasitic infection, inulin further exacerbates these pathological responses.

these data reveal that dietary inulin fibre triggers microbiota-derived cholic acid and type 2 inflammation

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#2

I don’t like it either, or it doesn’t like me. Anyhow, we’ve parted ways.

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#3

The six-week randomized controlled trial included 117 adults with knee OA and compared four groups: inulin alone, digital physiotherapy-supported exercise (PSE) alone, both treatments together, and a placebo. Inulin and physiotherapy each reduced knee pain on their own. However, only inulin improved grip strength and lowered pain sensitivity, which are measures related to how the nervous system processes pain.

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#4

Me too. It migrated from my stomach to my lungs. One capsule.

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#5

Gave me horrible gas. I cannot take inulin.

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