Let us know whether 3 mg or 7 mg is preferable after your experiment! 
3 mg is the starting dose, described as ânon therapeuticâ, to get used to the drug. So Iâm not using it.
1 Like
How much is Jagdish selling the 7 mg pills for?
For Rybelsus Jagdish quoted $55 for ten pills, 7 mg and $45 for ten pills 3 mg.
3 Likes
FYI. Just ordered that from Maulik (maulik7@gmail.com)
Rybelsus Semaglutide Tablets 14 mg x 30 - 129$
4 Likes
I hope you guys tolerate Rybelsus better than I did. I was so sleepy/exhausted I could barely keep my eyes open, and even then the appetite suppression wasnât dramatic. Subcutaneous tirzepatide, even at very low doses, worked SO much better (although increased HR and fatigue were still an issue to some extent).
That being said, there is a huge amount of variability in both responses and side effects with the GLP meds from person to person, so you may do just fine.
@cl-user you only ordered the 14mg tablets? I hope you arenât planning on starting at that dose if youâre new to GLP meds because you could end up in the hospital. Splitting the tablets may or may not work since they have a special delivery system through the stomach wall.
3 Likes
How long did you stay on rybelsus? No improvement over time? (I have almost zero appetite suppression on 7 mg.)
1 Like
You might have gotten the placebo version of it.
I managed to hang in there for 2 months and lost about 10 pounds, but definitely not worth the side effects for me. 3mg wasnât too bad, but 7mg was just way too much to handle, even after a month. Youâre probably already aware that the clinical trials with Rybelsus donât show much weight loss compared to injectable versions of GLPs, thus the rationale for Novo Nordisk currently doing phase 3 trials of 25mg and 50mg oral doses for obesity.
1 Like
I donât know if this is a joke, but you might not know that only 10% of people experience appetite suppression on GLP1RAs (but still lose weight!):
Iâm in this case: no appetite suppression but lost 5% weight.
This is incorrect; see this:
Rybelsus 14 mg is approximately equivalent to Ozempic/WeGovy 0.5 mg (source). The max dose of WeGovy is 2.4 mg. So, to achieve the same with Rybelsus you need 14 x 2.4/0.5 = 67 mg. Thatâs why they chose 50 mg. They found the same weight loss as semaglutide s.c. 2.4 mg: Effect of oral semaglutide on energy intake, appetite, control of eating and gastric emptying in adults living with obesity: A randomized controlled trial 2024
Consistent with the reduction in energy intake, participants receiving QD oral semaglutide 50 mg experienced a reduction in body weight of 9.8% (10.1 kg) over 20 weeks compared with 1.5% (1.6 kg) for participants receiving placebo. This is consistent with a previous study, which reported a 9.9% (10.4 kg) reduction in body weight over 20 weeks with QW s.c. semaglutide 2.4 mg.
3 Likes
Iâve looked at that and I donât see any reasons to not split the tablets. The following paper explains the mechanism of oral semaglutide absorption and the role of SNAC. SNAC is not on the coating but co-formulated with the semaglutide.
Worst case I could apply wax on the cut if needed. But everything Iâve read on the topic says itâs co-formulated not coated.
6 Likes
Find this very interesting and most likely works.
2 Likes
It is correct, if you read what I said. Oral Rybelsus (which only goes up to 14mg) causes less weight loss than injectable GLPs (since Rybelsus is âcappedâ at 14mg, equivalent to 0.5mg Wegovy which is quite a small dose and less than most people need). The higher dosed 25mg/50mg wonât be called Rybelsus but will have a new name for the new indication of weight loss.
If youâre a hyper-responder and donât get side effects, then congratulations.
Theyâre easy to split in half, but trickier to split into fourths. Good luck!
1 Like
Self-reported appetite suppression. The only known mechanism for pure GLP-1 agonist drugs like semaglutide is decreased calorie intake, whether people are consciously aware of their appetite suppression or not.
You wrote: âRybelsus donât show much weight loss compared to injectable versions of GLPsâ
This is incorrect. Oral and subcutaneous semaglutide lead to IDENTICAL weight loss as long as you use the equivalent doses (14 <> 0.5 or 50 <> 2.4).
1 Like
Youâre correct. However, at 0.5 mg s.c., whatâs the average reduction of energy intake in people without diabetes who are neither obese nor overweight? I assume not much, if anything.
1 Like
But you canât use identical doses of Rybelsus past the equivalent of 0.5mg Wegovy, which is too low for most people. This is why they are doing studies of the 25mg and 50mg tablets.
1 Like
Yes, of course.
By the way, this page says: âIn the EU, a new formulation of 1.5 mg, 4 mg and 9 mg doses of RybelsusÂŽ are approved and are bioequivalent to the original formulation of RybelsusÂŽ.â
Apparently, Novo Nordisk reformulated Rybelsus last year and removed two excipients: Novo Nordisk changes Rybelsus recipe to free up semaglutide for top sellers (does anyone have access to the article?)
However, Iâve never seen these doses in the EU. Theyâre also approved in Canada: Regulatory Decision Summary for Rybelsus - Drug and Health Products Portal
I wonder how they did this. And do the 25 and 50 mg tablets use the old or new formulation?
1 Like
AFAIK, it also metabolizes or uses as a fuel in thermogenesis, blood glucose. Double whammy in this case.
2 Likes