I take a combo of Apigenin (250mg), Magnesium l-threonate and l-theanine which works well for me for sleep latency plus I am hoping I get meaningful CD38 inhibition from the apigenin and anti-inflammatory effects too:
1 Like
Luteolin is an HDACi
2 Likes
Is an HDACi slightly stronger than Luteolin.
2 Likes
I have just obtained some Kaempferia galanga or aromatic ginger which contains reasonable amounts of seven Histone Deacetylase Inhibitors (HDACi s). I need to plan a time when I fit this into my HDACi testing routine which I think now has 18 HDACis divided into four quartets and a pair. They all tend to be in the micromolar range although some are in the millimolar range I would not want to use those in the nanomolar range. I think they may be too strong (and also they are not natural substances with histories of being used for human health for 100s or thousands of years). Hence too risky.
1 Like
Are there any specific markers etc you will be tracking in your testing routine to understand the effect each of these HDACis are having?
I take 3.5 mg of naltrexone every night and by that I mean whenever I can remember — mostly as an anti inflammatory.
I do weekly blood tests. (I did one today and hope to get the results soon) I also record a lot of things and particularly I monitor the effect on hair follicles (I was quite bald and that is reversing, but I can monitor new hairs starting, hairs turning from vellus to terminal and hairs getting thicker {ie the reversal of miniaturisation})
The objective is better cellular function. The effect of that is in producing a wider range of proteins. Hence when I get more skin oil that is a good result.
At the moment, for example, I am making process with my chinups having added 10kg of extra weight to my legs. This is a good test of protein expression contrary to sarcopenia.
However, in a few moments I am off to the pub with my daughter. I have had two days of limited calories interspersed with two days of fasting and I feel like a drink.
To add to this. I am currently experimenting with HDACi s in groups of 4 because there are too many of them to just test one at a time.
2 Likes
@John_Hemming May I ask for your opinion on pros and cons on Luteolin vs Apigenin regarding their effect on healthspan?
I have no evidence on this.
1 Like