Inflammation as a Key Target for Longevity

#21

A better, modern clock, Linage2 (LinAge2: providing actionable insights and benchmarking with epigenetic clocks | npj Aging) includes cholesterol, CRP, and several other inflammation indicators.

You are correct though that inflammation is a big player in CVD, and brand new guidelines agree with you. They now say that CRP and other markers should be taken into consideration and targeted for treatment in the same manner as cholesterol: https://www.jacc.org/doi/epdf/10.1016/j.jacc.2025.08.047

The problem is, lowering inflammation is very tricky because it’s so hard to define. CRP, ESR, various cytokines etc are only indicative, and all of them are non-specific. You can also be terribly unhealthy and those markers are totally normal.

I think D-Dimer is another under-rated inflammation marker, as is ferritin. Worth looking at those too IMO.

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#22

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

Associations Between Fibrin D-Dimer, Markers of Inflammation, Incident Self-Reported Mobility Limitation, and All-Cause Mortality in Older Men

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#23

I take statins to lower inflammation as much as apob.
I have a cor one i havent used much in a while. Its hard to keep doing experiments without an algorithm.

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