Mild cognitive impairment is associated with increased levels of myo-inositol in certain areas of the brain. Increased myo-inositol is also a biomarker that correlates with a pre-alzheimers state in the brain. I would really like to get some feedback on this and how to interpret these findings. (I am sorry I could not find links with previews to two of the papers).
I know that myo-inositol has shown benefits for other brain diseases, like mood disorders. But I would like to explore the correlation with Alzheimer’s and cognitive impairment.
“A strong correlation between brain metabolite accumulation and oxidative stress has been observed in Alzheimer’s disease (AD) patients. There are two central hypotheses for this correlation: (i) coaccumulation of toxic amyloid-β and Myo-inositol (MI), a significant brain metabolite, during presymptomatic stages of AD,and (ii)enhanced expression of MI transporter in brain cells during oxidative stress-induced volume changes in the brain. Identifying specific interactive effects of MI with cellular antioxidant enzymes would represent an essential step in understanding the oxidative stress-induced AD pathogenicity.This study demonstrated that MI inhibits catalase, an essential antioxidant enzyme primarily inefficient in AD…”
I use myo-inositol in the morning and at night, so this is a concern. I use it in the evening because it might help me stay asleep better and in the morning hoping for a little help with the blood glucose level. I have to read the text through.
” This study investigates the role of myo-inositol (MI) in elderly patients with mild cognitive impairment (MCI) or cognitive impairment associated with depression. The research measured MI levels and MI/Cr (myo-inositol/creatine) ratios in different brain regions, particularly the frontal lobe, posterior cingulate gyrus, and occipital lobe.
Key Findings:
MCI Patients: These patients had significantly higher MI levels and MI/Cr ratios in the frontal lobe and higher MI/Cr ratios in the posterior cingulate gyrus and occipital lobe compared to healthy controls.
Cognitive Impairment Related to Depression: MI levels and MI/Cr ratios did not significantly differ from healthy controls, and there were no significant differences between MCI patients and those with depression-related cognitive impairment.
Differential Diagnosis: Elevated MI/Cr ratios could help distinguish MCI patients from healthy individuals but do not differentiate between MCI and depression-related cognitive impairment.
Does This Finding Apply to Myo-Inositol Taken as a Supplement?
This study does not directly address myo-inositol taken as a dietary supplement. Instead, it examines MI levels in the brain in relation to MCI and depression-related cognitive impairment. The study found elevated MI levels particularly in MCI patients, which could indicate increased gliosis (the proliferation of glial cells in response to damage).
Potential Negative Associations: If myo-inositol is consumed in large amounts as a supplement, it could theoretically influence MI levels in the brain. However, this study does not provide direct evidence of this. The research suggests that elevated MI levels may be associated with pathological changes like gliosis, which could be related to the development of Alzheimer’s disease. This implies that excessive myo-inositol supplementation could potentially be harmful, particularly for individuals at risk of cognitive disorders, but further research is needed to confirm this.”
I don’t want to put it on my drop list. It has too many good qualities. Especially taken with IP6. But yes, I need to get an understanding of the correlation that the papers show. Some have even suggested that myoinositol could be a potential treatment for dementia-Alzheimer.
Not much to say. I have it in my cabinet. I don’t use it anymore. it might be good for cancer prevention or to aid regular cancer treatments. And good for sleep and mood disorders.
But my top priority is cognitive health. A long life with a dementia that transforms my brain so i don’t recognize my kids and I don"t live in the same universe as them. That is not the long life I want. And since myo-inositol are correlated with brain disorders, it raises red flags for me. it might just be smoke, but I reduce my stack and I can use other things where there are less disturbing correlations.
“Down syndrome (DS) is associated with trisomy of chromosome 21 and is the most common genetic cause of mental retardation, occurring in approximately 1 in 1000 live births. The neuropathological features of Alzheimer disease (AD) occur in virtually all individuals with DS older than 40 years,1 and the prevalence of dementia in people with DS in their 50s has been estimated at 66%.”
Down Syndrome has many defects with it so it might be a great discovery if lowering myo-inositol would cause a substantial improvement.
The proof of the pudding might be if increasing myo-inositol in marmosets or higher primates would affects memory negatively …
mI levels are elevated already at asymptomatic stages of AD. Moreover, mI/creatine concentrations were increased in healthy APOE ε4 carriers with normal CSF Aβ42 levels, suggesting that mI levels may reveal regional brain consequences of APOE ε4 before detectable amyloid pathology.
In conclusion, our findings demonstrate that the longitudinal changes in mI/Cr (myo-inositol.creatine) and NAA/mI (N-acetyl aspartate/myo-inositol) are largely governed by the presence of underlying amyloid pathology, warranting their potential usefulness as noninvasive dynamic disease biomarkers during the predementia stages of AD. Today, amyloid and tau deposition can be imaged using PET, allowing us to assess molecular pathology in vivo. However, the need remains for a more widely available cost-effective technique that can be used for screening dementia and monitoring disease progression and treatment effects in a clinical setting. Large-scale multimodal studies that include MRS will help further locate spectroscopic changes in the continuum of AD pathophysiologic processes.