FWIW
Review Marek Diagnostics, they also use LabCorp
The rapamycin test cost less than $60.00 through Marek.
See the link below, has discount codes posted
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Thank you, do I pay Merk and will they send me the order for me to go to Labcor?
Thank you
There are a few States that are not allowed NY, NJ and RI.
Contact customer service and ask before you pay. As they do not issue refunds.
I am in a NY, NJ area, I have to go to PA to use.
Ok thank you, I live in Florida
Thank you, I now have the requisition
From Marek to test my blood after 6 months of dosing with Rapamycin.
If possible post how it worksout.
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Hi
I ordered the Marek blood work order but I havenāt had an email with the confirmation yet, how long does it normally take? I ordered it on Sunday, today is Tuesday
Thanks
I sent a request and for some reason (over the weekend) it didnāt get filled and they never sent the email. After contacting them a week later they finally sent it. It appears they have minimal staff to deal with these things. Iād send an email if you havenāt received the requisition in 3 working days. BTW because of this (I was doing a peak and trough) I had only one requisition so I just ordered the second test directly at labcorp (MD). The Marek test was 60 and the one I ordered directly was 220 or something close, I called to complain and they reduced it to 160. Lesson learned.
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Thank you for that information. I sent a requisition over a week ago but have heard nothing, I will email them
Thanks again
We asked to ChatGPT to write a supreme court brief. It made up supreme court cases and cited them in its brief!
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You should get the requisition the same day. I think mine went to the spam file. You can call them.
I will call them, I have emailed them 4 times but no response
Thanks
Has anyone experience from using ritonavir? Any sideffects from short time use?
āRitonavir is the most potent cytochrome P450 (CYP) 3A4 inhibitor in clinical use and is often applied as a booster for drugs with low oral bioavailability due to CYP3A4 mediated biotransformation, as in the treatment of HIV (e.g., lopinavir/ritonavir) and more recently COVID-19 (Paxlovid or nirmatrelvir/ritonavir). Despite its clinical importance, the exact mechanism of ritonavir-mediated CYP3A4 inactivation is still not fully understood. Nonetheless, ritonavir is clearly a potent mechanism-based inactivator, which irreversibly blocks CYP3A4.ā
Since it is āthe most potent CYP3A4 inhibitor in clinical useā There should be a substantial amount of clinical experience from the widespread use.
I had good experience with Marek. In fact, I just got my sirolimus blood test result back, 5 days after the draw at my local Lab Corps.
They do seem to have some problems with their email automation. Just keep after them.
All good now thank you, there was a typo error in the email address, received the order now thank you
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why your data is different with the data of link?
The reported changes in exposure correspond to the changes in the plasma concentration-time curve [ AUC ]. Itraconazole exposure increases to 511%, when combined with sirolimus (511%). This can lead to higher incidence rate of side effects. Sirolimus exposure increases to 491%, when combined with itraconazole (491%).
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Thats Strangeā¦ they must have changed it after I copied it.
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If the effect is five times better, I think I can take itraconazole first, and then take sirolimus after reaching the peak in 4 hours. After all, some seasons do not have grapefruit.
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AUC area under the curve or how slow / fast rapamycin is being metabolized, Cmax (which is how much rapamycin is absorbed) is not mentioned. Has anyone any idea on Itraconazole? I read it has a really long half life, which means it would potentially affect / inhibit CYP3A4 in liver for much longerā¦ Grapefruit inhibits CYP3A4 mostly in intestine thus mostly increasing absorption and Cmax not extending the AUC. Ketoconazole has a relatively fast half life and minimally extends the AUC per what I have read.
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From what Iāve read, Crestor(rosuvastatin) is one of the statins not affected by grapefruit.
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