Improve Bioavailability of Rapamycin (2)

Apparently this Rapamycin he’s referring to was Zydus:

Also for what it’s worth ive been taking 6mg of Zydus for the past few weeks (I just started Rapamycin) and have had a mouth ulcer and high postprandial glucose after my Rapa dose for 24-48 hrs (with higher carb foods). These seem to be common side effects of Rapamycin, so that’s something.

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Yes, I got 3 canker sores after I took my 2 mg dose of Zydus + GFJ yesterday. Makes me wonder about my immune system. Although I have been exposed to COVID frequently and have never gotten it. So I am not sure how good my immune system is.

Although there is no euphoric or nauseous feeling like I had last week. That was probably due to dehydration due to cycling in very hot weather.

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It has been suggested that such capsules are not truly enteric coated. It appears the capsules are not ‘airtight’ where the two halves meet and liquid will still be able to get in and out of the capsule. (I believe it was Mac who suggested this, and he may very well be right about that).

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@curt504
Thanks a lot for your comments above. Could you please report your next test when using the Grapefruit juice and also the exact brand of your generic rapamycin.
Many thanks.

Not all statins. Crestor is fine with grapefruit

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I really don’t worry too much about the bioavailability of the major producers of generic rapamycin (e.g. Zydus, Dr. Reddy’s and Biocon) because these drugs are used for organ transplant patients. These drugs are used by hundreds of thousands, (if not millions) of organ transplant patients. If there was a significant bioavailability issue with these drugs, so much so that they were not doing their intended job, the negative press would be huge and the number of dying patients would be obvious to anyone.

The bioavailability issues that we’ve seen in the compounded pharmacy capsules are a tiny slice of the market, and thats why its been noticed and reported quite a bit around here and others. Just avoid the compounded pharmacy capsules and you’ll likely be fine.

Just my opinion on this issue.

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Just saw this today, confirming what I said earlier - that generic and brand name rapamycin / sirolimus are both good from a bioavailability standpoint:

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Berberine also blocks CaKG according to the CEO of Rejuvant. Rejuvant is a time release CaKG that their web page claims reverses biological age by 8 years…

That’s good to know because I take generic Crestor 3 days a week. I have been taking rapamycin with grapefruit juice on one of my off days from Crestor.

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Biocon works, I feel it when I workout. It takes about a week after I take it to get back to normal strength. IIt seems to hit hardest mid week (I take it on saturdays) That’s one of the reasons I take it semi-monthly. I like a week off to feel normal

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@RapAdmin
I really don’t worry too much about the bioavailability of the major producers of generic rapamycin (e.g. Zydus, Dr. Reddy’s and Biocon) because these drugs are used for organ transplant patients. These drugs are used by hundreds of thousands, (if not millions) of organ transplant patients. If there was a significant bioavailability issue with these drugs, so much so that they were not doing their intended job, the negative press would be huge and the number of dying patients would be obvious to anyone.

Have you tested yourself? I’ve asked in a Lab here in Perth, Australia, and I need a prescription for the test. So it is going to take me a while till I find a doctor to give a prescription. Therefore, my tests will have to wait.

But what about you? You expressed interest on testing yourself, it would be nice if you could test Pfizer, and some generics, with and without Grapefruit, with and without Fat. I know I’m asking a lot, but even just a piece of comparison between two cases would be great. For example just the plane Pfizer vs Generic.

Many thanks.

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I agree with his point about the major producers of generic rapamycin tablets. It seems a waste to personally pay out of pocket for a bunch of personal “n of 1” bioavailability comparison lab tests given that so many organ transplant patients take these generics and have their trough levels tested without apparent problems.

I think most of us are interested in the serum rapamycin tests because we’d want to know peak levels with/without grapefruit juice and at any particular dose and we want to look at trough levels to make sure we have an effective washout period between doses.

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In what way / direction does it work?

I did a little test today where I filled the delayed release capsule with oil and placed it in vinegar. I swirled the glass once every 15 minutes. It took 3:15 until the capsule started to break down to the point where any oil was released. @MAC you might be interested as well.

I’m considering loading up 6mg of my Glenmark Sirolimus tabs into the capsule. I do wonder how they prevent it from breaking down otherwise. I wish it were easier to get a serum level!


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I go to the same fitness classes 4x week. Days 2-5 after taking my semi monthly dose I can feel a lot more struggle doing my fitness routine. My stamina and strength is negatively impacted. I feel weaker and run down.

About 7 days after my dose I’m back to feeling my normal strength and energy levels along with no body aches or pains.

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That is good news. Thanks for trying that out. Would you mind sharing the link to place/webshop where you bought the capsules? I may want to give this a try also.

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if you get side effects such as canker sore with higher dosage, then you know it works. i took 5mg of Indian-made everolimus, two times i got canker sore the next day.

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Canker sores are really variable though… I have had one only once in three years, as my dose varied from 3mg/week to 28mg, so its not a good indicator for many / most people.

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I had three canker sores this week. Yes, it varies greatly from person to person.

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