Hi All, I may be unique with my rapa absorption problem, I can’t swallow pills. All pills need to be blended into a slurry in a bullet grinder. I blood test via the lifeextension.com via labcorp sirolimus blood test ($99). You have to call their support number then ask for blood testing, support and eventually they will find who can sell this test. Its not on their website.
First of all; any have a good guess at what blood concentration I should be shooting for? 20ng/ml? 40ng/ml? The blood test states a range of 3-20ng/ml. I’ve seen absorbtion studies in this threa mentioning 40 and up to 70ng/ml…
My highest test results so far is 7.2 ng/ml and this was after this dosing protocol;
- each day, 2 days every 2 weeks; In the morning; (attempts to increase aborbtion) 1T dried GF powder, 1T GF extract, peperine 10mg, 2T olive oil. I’ve already been filled in re the value of frozen GF concentrate vs my attempts to be simplier with dried GF powders.
Then 2 hrs later, giving time for CYP34A to be suppressed.
2t olive oil + 10mg via 1mg indian sourced sirolimus pills, tossed in 6mg via diluted down pure chinese powder (just for good measure). IE kitchen sink approach.
One the 3rd day I had blood draw for the sirolimus blood test and got 7.2.
== Improvements I’ll add gleened from above (thanks all)
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During the pre-dose dose I’ll add additional CYP3A4 suppressors:
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1/2 can of frozen GF concentrate. Yes giving in and just have this product flowing through the freezer.
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1g berberine
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1g fiesitin
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1g sodiumm caprate (an MCT/coconut oill derivative)
Then reblood test.
=== General comment to other DIY rapa experimentors.
Given my close inspection of my indian 1mg pills, I found them to be fragile, easily broken and crushed. I wonder if they are at all enteric? Disolve in the stomach much likee my grinding and drinking a slurry?
You guys may not be achieving the blood levels that are beneficial?? Given the risk to true benefit and variability of the sirolimus / rapa drug pill / supply chain. Do you really know what blood levels you are achieving?
Just a comment; I would suggest that everyone doing this protocol should do at least a few blood tests to verify for their (your) stomach, pills, protocol you are really getting the benefit you want.
I agree that canker sores and other symptoms are useful.
Rambling a bit; My opinion re canker sores to me says; your immune system is marginal to begin with and the initial function of rapa to (in theory temporarily knock down your immune system) causes the always present canker sore (like shingles like many lurking bugs). My question is why is your immune system marginal in the first place? Just questioning.
Not sure if my having no symptoms post rapa means much good or bad. Just plodding along, collecting data.
Not detailed; I do a 2day dosing of the classic D+Q+F (and kitchen sink add ons) scenolitic protocol on the alternating weeks.
Best to all, curt