In general, per my studies, raising all hormones, thyroid, T, E, P, to 30-40yo levels is protective of every cell, organ, and their function. Re T being good vs bad for PCA / BPH/prostrate. T is good, a protector.
Best to all, curt
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I would guess physiological is fine as well. But without controlled testing on this, we won’t really ever know. Someone with 400 test compared to 1100 may have less involution in the first place and an accelerated rate of regeneration since he is chronically lower in androgens.
Either way, the protocol still works and I have a high physiological test level, so I will just do the 12+ months of the TRIIM protocol.
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Exactly, I am now 6-months into the TRIIM protocol using HGH recently purchased from China and DHEA 100 mg with 3.3 iu nightly shot.
Not using metformin - tried it - my body hates it. But, going to ask my GP for a prescription of INVOKANA - Canaglifozin instead next week…
Muscle growth and skin quality great while on HGH.
Will get my IGF-1 result this week.
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Don’t even get me started on this. I couldn’t agree more.
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There’s a really great discussion of hormones and longevity included in one of the more recent videos from Siim Land.
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This from another post - seems to prove Dr. Fahy could be very wrong that rapamycin is detrimental to T-cells. See below.
In experiments, human T-cells exposed to a DNA-damaging drug fared badly – most didn’t survive. But when rapamycin entered the mix, the picture changed. Damage was reduced, and three times more cells survived. The effect appeared within hours, pointing to a direct protective action.
Ghada Alsaleh, an Associate Professor at the University of Oxford, explained that rapamycin consistently produces the same effect, whether it’s given before, during, or after the damage occurs.
Study co-author Lynne Cox said the effect happens rapidly – within about four hours it appears to influence the DNA damage response and the buildup of lesions.
A cautious endorsement
Matt Kaeberlein at the University of Washington sees the study as strong evidence that rapamycin protects DNA. Yet he emphasizes the mechanism remains a mystery. The next step is to track how the drug changes RNA and protein activity inside immune cells.
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I think Fahy spoke before realizing he was looking at daily dosing Rapamycin evidence, which seems to be the dosage frequently associated with negative effects.
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Daily dosing will mean chronic inhibition of mTOR.
I am currently taking rapamycin no more frequently than every 6 weeks. But I take a lot and with a multiplier.
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Yes… I think he is a great specialist in his thymus research, but certainly not in rapamycin. There it is Matt Kaeberlein.
And, Fahy was off on rapamycin dosing amount and frequency. He thought the positive immune response of rapamycin was repaired t-cells… which the DNA protection, recovery… might indicate
But, said new t-cell production would be inhibited by rapamycin. I hope he’s wrong. Lol.
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About GLPs: I am the moderator of a group for people who have suffered an NAION attack of the eye. This is a rare but shocking condition that usually occurs overnight. You wake up and have a huge deficit in one eye. Many eye docs do not even know what this is. It is permanant because it is caused by a mini-stroke in the tiny artery that serves the optic nerve. Anyway, in the past year we have had an uptick of members who started a GLP medication that seems to have caused this, and then there have been a few journal articles about it. I highly recommend that anyone who wants to start on a GLP med should first go to a neuroopthamologist and have a simple look into both eyes to see if either has a “Disc at Risk” also known as a low cup to disc ratio. If you have that I would not proceed and would be very careful to keep my blood pressure in the normal range, espcially if under anethesia. That is about all you can do to reduce your chances of NAION.
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Isn’t the rate for this condition like one in a million for diabetics on GLP1? How many people are in your group exactly?
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Currently there are 226 members. The one in a million number is likely a guess and could be simply due to the rarity of the condition. I am merely suggesting that you get tested before starting GLP. Oh, and the other possible cause is sleep apnea. These are both preventable factors
Do any reliable sources in India carry Jatenzo?
Where do those of you who take test cypionate without a prescription get it if I may ask?
I have got my labs in and have low normal total T, pretty high SHBG, so very low free T, even for a woman. My obgyn prescribed me gel packets to use 1/10th the male dose of, but they’re very expensive even with goodRX. The injectable t cypionate is very cheap and I’d be getting it twice a week, micro dose. My obgyn isn’t very comfortable with it as she hasn’t prescribed it to a woman before. If she doesn’t budge I’d like to know where I can get a safe version of it at a good price, the equivalent of a vetted peptide manufacturer. Does such thing exist or do you guys always get it with a prescription?
And I’m not comfortable ordering from India. I already tried, with the gel tubes, and it was confiscated at customs so now I bet my address is black listed. At any rate won’t be trying it again.
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You could try an online provider, I know that Defy Medical, for example has a variety of options for delivery: injectables, pills, pellets. The price might not be too cheap, but at least you would have the option of using the injectable option.
“Safe” version from anything that’s doesn’t come from a pharmacy or drug manufacturer doesn’t exist, unless you’re ready to test what you buy for concentration, GCMS, etc.