I'm 23. Should I start taking rapamycin?

At time 33:08 of his podcast with Matt Kaeberlein, Peter Attia makes the following claim:

I have no honest clue what’s the right age to start rapamycin, but it wouldn’t be before 25.

My chronologic age is 23, but according to a recent epigenetic test that I’ve done, my biological age is in the early 30s. Obviously this is not great news, but I know the causes: I had a poor diet for the vast majority of my life, I slept poorly during high school, and I did not exercise for ~4 years after finishing high school. At 22 I had an epiphany about my health, which has completely changed my lifestyle. Nowadays I would describe myself as a full-blown longevity junkie.

Should I start taking rapamycin, or should I just focus on maintaining my healthy lifestyle (good diet, restful sleep, regular exercise) for the time being?


In the recent AMA Dr Green arbitrarily suggested 38 as the age to start though all agreed ‘we just don’t have the data’.

Intuitively I think the benefits seen from rapamycin are inversely correlated to an individual’s starting health. By that rationale a 70 year old may see a profound effect but a 25 year old, ‘no change’.

That said there could still be an aggregation of marginal gains that are undetectable over short time frames.


FWIW if I where the same as you stated above, I would add rapamycin for 12 week on 12 week off for a year and recalculate to see if there is a change. Your statement says you are 30% older biologically.

“If you wait until you are ready, it is almost certainly too late.” ~Seth Godin

Above quote in Mikhail V. Blagosklonny paper;

Rapamycin for longevity: opinion article


I would say to wait until 30, and in the meantime focus on behaviors
There may be some downsides to shutting growth off in any way at your age.
I would also assume that by the time you hit 30 we will know a lot more.
So I see your potential upside fairly minimal by starting now

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So I am 24 ( I turn 25 in August), and I have been taking rapamycin 1mg/week for about a month now. My epigenetic test says I am 16( I use the levine phenotypic sheet) , I am pretty sure the sheet does not accurately depict younger individuals. But I am taking rapamycin more so to prevent degradation and maintain health. I am not expecting any results more so as it wouldn’t hurt.
I would continue what your doing in regards to healthy lifestyle and then figure out what your phenotypic age is after a couple months, then after doing that , maybe think about rapamycin in a year or two. But if your age is that high phenotypically, I think the healthy lifestyle is going to bring about the bigger changes.


I would first focus on getting my healthy diet/exercise program fully established and in practice for a year or two, doing periodic blood tests to track progress, and only after that - perhaps when you are in your late 20s, consider adding rapamycin to the mix.

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Thanks everyone for your feedback :pray:

Very helpful.

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There are large error margins and confounding factors in epigenetic tests. Don’t believe the age 30 “estimator”. The site itself has so many disclaimers that people tend to not read.

I heard about rapamycin when I was 25 and I was already a huge biochemistry nerd at the time. I didn’t take it for many reasons. There are risks with any drug and rapa is no exception when it comes to a developing adult (i.e. bone deposition and resorption ends in late 20s).

I personally focused on the low-hanging fruit first - diet, exercise, sleep, and high socioeconomic status/chronic stress before taking it at age 30. That being said, nobody knows what the best age is. Period.

Consider WGS from a CLIA-certified lab or join a clinical trial. Don’t waste your time on DTC labs that are not well validated.


Thanks for your remarks, @tongMD.

Yeah I’ve also grown more skeptical about epigenetic tests in the meantime.

I wasn’t even finished growing at 23…, I think I added 1-2 cm between 23 and 25

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