Yes - hyper function theory of aging, and antagonistic pleiotropy all wrapped up in one 
Hyperfunction theory of Aging:
https://www.aging-us.com/article/203937/t
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After taking rapamycin for a couple of years, I am on a 2 month break that probably ends in March. Before I restart, I’ll report on my IGF-1 as a baseline and get it remeasured three months after that. Any problems with allowing 3 months to establish a possible change in results?
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My test results, after a 2 month layoff of rapamycin, followed by 4mg rapamycin with 10oz grapefruit on a Friday, then the IGF-1 test on Monday: 74ng/mL (reference: 68-247). I’m in the 25th percentile as a 60yo male, which sounds good to me for longevity purposes. I’ll test again after a couple of months of intermittent rapamycin.
from https://www.semanticscholar.org/paper/Serum-insulin-like-growth-factor-I-in-diabetic-Payne-Tangpricha/54e1e0d8f03c06b328df601e60028999553ee658
According to this:
THE HYPOTHALAMUS AND PITUITARY PART II
plasma half-life of IGF, which is around 12 h
so perhaps at least part of my lower-but-normal IGF-1 is due to the rapamycin 3 days earlier.
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New Open Access Paper Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans by Elizabeth M. L. Duxbury & AlexeiMaklakov et al.
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