I follow the lead of Dr. Mikhail Blagosklonny who knows more about rapa dosing than all of us combined.
He is currently taking 20 mg. twice a month without side-effects. I have the same dosing schedule for the last 4 months without incident. Knowing that we are all different, Dr. B recommends everyone be under the care and guidance of a physician.
4 Likes
Bringing back an old thread… Feels like the average dosage on the forum is trending upwards? (Still keen to know people’s mg/kg!)
If I recall correctly the (mostly mild) side effects of 20mg per week reported in the Mannick trial still weren’t that much higher than placebo?
2 Likes
FWIW…The only way to know what “your” personal blood level dose would be is the measure. As I have stated in an another posting;
Base draw
Take dose
30 minute draw
1 hour draw
2 hour draw
3 hours draw
4 hours draw
At $95.00 per draw/test the cost would add up.
A base to 8 hours, $1,000.00{$95 x 10] Try to negotiate a lower cost with the lab running testing.
Yes - but I suspect the number of people who would want to spend the day hanging out in the LabCorp or Quest office doing blood draws is pretty small. Plus - you would ideally want to do this at different dosing levels - say 10mg, 20mg, 40mg, etc.
It would be interesting to have a clinical trial / study done on this type of model in healthy people of different ages (e.g. age 30, 40, 50, 60, 70). I wonder if this type of information would be more generalizable to the broader healthy population…
2 Likes
So why are people wanting to take higher and higher doses of rapamycin? I am wondering if you really are seeing any addition benefit by taking these higher doses in comparison to just taking rapamycin in general. I mean we do not want MTORC2 inhibition and I am wondering on top of rapamycin a lot of people on the forum are generally practicing good lifestyle practices that may influence some of the results they are seeing while on rapamycin. Now, I am a believer in rapamycin and like the data that comes out ( I am trying to stay unbiased and objective) but I see a lot of people on the forum combining so many supplements and different lifestyle approaches that its hard to single out what is actually being effective for them. I also see a lot of people constantly looking at research articles and trying the next “new” longevity thing and it almost seems like its done in a anxious fever. I just am curious why people are trying to up their doses to higher levels? I am just trying to understand others logic in this, especially since I am so young and havent felt the impacts of aging yet.
1 Like
I think the key reason people are wanting to take higher and higher doses of rapamycin is that in the ITP studies, the higher the dose of rapamycin, the longer the life extension effect found in mice. Additionally, numerous people have reported taking very high doses of rapamycin with little in the way of side effects (though this has to be monitored closely with regular blood tests) - so more generally people are testing how their bodies are responding to rapamycin. Most of us experience few if any side effects - so the natural tendency is to see if we can go a little higher and still maintain the same low side effect profile (while also increasing the time period between doses so as to not inhibit mTORC2 - and risk the immune suppression problem that goes with high, ongoing/continual dosing protocols. Search on the forum (top of page search icon) for “higher doses” and you can see many past discussions on this topic.
Here is one example of perhaps the highest dosing I’ve heard of - he seemed to be doing OK until he took a dose near the same time as the vaccination. High Doses of rapamycin by one user.
See below:
Rapamycin Lifespan Improvement given different Doses from the NIA ITP Studies
1 Like
Why?
Anyone taking rapermycin know what is their optimum dose is to turn off mTOR1 in their body?
We are all PFA* dosing.
- Plucked From Air
1 Like
Yeah but is the higher dosing making a significant difference in comparison to low-moderate ( or just generally taking rapamycin period) dose in terms of lifespan increase outside of the one study? I am just curious how one would even quantify the difference in lifespan in terms of percentages when applied to humans? I mean if its only making lets say a difference of a couple years , I feel like just taking rapamycin in general is enough to increase the lifespan and not really worth spending the money on higher dosing
1 Like
For what it’s worth, it’s not clear that mTORC2 inhibition is always “bad.” I recall Dr. Matt Kaeberlein saying this in one of his interviews. For longevity purposes, perhaps there is a sweet spot where a bit of mTORC2 inhibition is actually beneficial.
See for example:
5 Likes
I am not sure, I think an old peter attia podcast with david sabatini talks about it and Dr. Sabatini said that you really would want intermittent inhibition of MTORC1 and no effects on MTORC2, if i remember it correctly.
It isn’t “just one study” - it is 3 or 4 studies by the ITP, which are themselves a group of studies done at three different labs at the same time - so effectively 9 to 12 studies, that have shown higher doses equal longer lifespan effect (in mice). Plus - many other studies done by many other labs - as outlined in the complete list of rapamycin mouse studies.
So - its over a decade of dozens of studies… pretty robust data.
3 Likes
Gotcha. I guess what I am asking is the studies done with rapamycin and increase of lifespan, would it make much of a difference if one just practiced general health guidelines(like exercising, eating healthy, routine doctor visits) and take low to moderate dose of rapamycin, in comparison to these really high doses. I imagine too much of anything for the body is going to be consequential down the line( although taking the time period off might negate that). I guess I am just wondering from a lifestyle perspective if taking the high dose is worth the cost financially/ risk of unknown in comparison to just low to moderate dose while doing healthy practices. Its actually part of the reason why I am excited for Dr. Brad Stanfield’s clinical trial with rapamycin and performance as we get to see a combination of both practices put together.
Again, just trying to understand different perspectives, especially since rapamycin is something I will be taking for a long time( if all goes well in terms of my body’s reaction)
2 Likes
Ah - this is a great question, that nobody has the answer to yet. Definitely a lot more research needs to be done on this topic. As @Joseph mentioned - most of what people are doing right now is PFA dosing - we really don’t know what the right dose is, for ourselves personally and given our own health considerations, or more generally for any group of subgroup of people.
4 Likes
For members here who have not reviewed an older Attia Interview, listen to #118 aired July 09, 2020, on rapermycin with Lloyd Klickstein. Should give you a good understanding.
4 Likes
In one of MKs phase one dog trials I believe he compared 0.1 to 0.05mg/kg three times per week. He then settled on the lower 0.15mg once per week for TRIAD which presumably was to minimise side effects and maximise compliance. Does anyone know how the 0.1x3 performed in the initial trial (albeit with a small sample size)?
1 Like
“My perspective with new drugs has always been to let someone else be the early adopter / Guinea pig” Well that’s me, the early adopter/Guinea pig. LOL
Sorry folks, at 81 I don’t have time to wait for other early adopters.
I started out at 5 mg/week and started increasing to 10, 15, 20 mg ~ twice monthly. I have been on the 20 mg dose for approx. 3 months. The last 2 doses I took with grapefruit juice before and after.
The only adverse side effects I have experienced so far are a temporary spike in blood pressure, increased cholesterol levels, and an increase in flatulence and loose stools for a few days after the 20 mg dose. ( I am not sure that higher cholesterol levels are a negative thing. I seem to be moving towards the sweet spot of all-cause mortality levels found in this article; Association between low density lipoprotein cholesterol and all-cause mortality: results from the NHANES 1999–2014 | Scientific Reports)
7 Likes
Is that 20 mg plus grapefruit juice before and after? Or is that the calculated effective dose based on the gfj effect?
1 Like
Matt discussed it in this podcast. The results were good - especially on heart function, which I think was the primary endpoint they were looking at. Below is the paper that resulted from it, and the podcast where they discussed the results:
1 Like
It’s 20 mg Rapamycin + grapefruit juice.
2 Likes
Hi desertshores. From my reading of the literature, the grapefruit juice inhibits the intestinal CYP3A4 enzyme, thereby increasing absorption of the sirolimus from the gut. Therefore, the grapefruit juice taken after your dose would not be expected to help absorption much.
For what it’s worth, here’s my current biweekly protocol: one whole grapefruit with dinner ~12 hrs prior to dosing, and another grapefruit ~1 hr prior to dosing in the morning (as well as 500 mg metformin and ~1/4 teaspoon of black pepper for potentially more CYP3A4 enzyme inhibition). I take the sirolimus tablets with two small avocados (as a source of fat) in an attempt to further boost the rapamycin levels. There’s more discussion on this topic in the forum thread titled “Improve Bioavailability of Rapamycin (pt 2).”
By the way, thank you so much to RapAdmin for creating this wonderful website! 
Your efforts are much appreciated!
4 Likes