I metabolize rapamycin quicker than normal - good or bad?

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#1

Hello everyone. I take 3-4mg rapamycin weekly and sometimes fortnightly for anti aging.

I recently found out that metabolize rapamycin faster according to my dna genetic information data.

I understand that rapamycin is metabolized by CYP3A4? correct me if wrong) I have the CYP3A41B Variant (faster metabolize variant) I don’t have the CYP3A422 variant which makes you metabolize drugs slower, and I also have CYP3A5 non-expression variant which apparently makes me metabolize rapamycin even more.

If I metabolize rapamycin faster , should I stick to weekly rather than bi weekly, and should I increase my dose to something higher? I am thinking the reason I don’t get side effects is due to my body removing the rapamycin quick,I guess its a good thing, but also maybe a bad thing in a way, as I wont get much MTOR inhibition if the rapamycin metabolizes quicker?

any information/suggestions, would be great.

Chatgpt:

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#2

Its probably a situation in which to use a blood test for Rapamycin levels one week and then the next. (without a dose in between).

#3

I agree with John, my thought is that without blood testing, “faster” is not a real measurement :slight_smile:

There are several good posts here about how to measure the metabolism process accurately.

Since there is currently no hard and fast definition of dosing Rapa, metabolizing it faster is probably not an issue until there is more definitive information on what dose is truly effective, based on large human trial results.