I was considering Hyperbaric Oxygen Therapy, but this study, showing it may have negative effects on the gut biome, tipped the case against it for me, together with the fact that I get one of the goodies of HOT, immune strengthening, for a fraction of the cost and time with peptide Thymosin Alpha 1.
There is a lot of debate about the mechanism of HBOT. I purchased a liveo2.com adaptive contrast system that I can cycle between very high O2 (85+%) to very low (10%) and do this while exercising (EWOT). Seems like this will create a large hormetic effect between hypoxia and hyperoxia states.
How long have you been using it, how often and for how long?
I ask this, if you considered in you N=1 experiment testing your telomere lenght before and after 90 days, to evaluate if the stimulus corresponding.
Fabio
The key thing about HIF is that it results from a change (reduction) in partial pressure of oxygen.
just started - did get a trudianostic age test before starting so will look again in a few months
You can get faster feedback by tracking your sleep breathing rate. Lower rate means more co2 tolerance. Nasal breath while sleeping also helps.
Paul, your home experiment feedback is extremely valuable, i’m cross-referencing your feedback on my other attempt to achieve a similar oxygen playground but while sleeping, it would be way interesting to come up with some data on effectiveness on telomere length (that’s a way known benefit of HBOT alternating oxygen protocol at 2ATA), but without expensive/dangerous/complicated HBOT device.
Are you also tracking your VO2Max? I’d be interested in pre and post testing for that…
in a way. My Oura ring has a 6 minute walk test that provides a VO2 max number
Cross posting this thread where we’re discussing the potential benefits of hypoxia: Oxygen, hypoxia and hyperoxia
I wonder if a significant part of the benefits of HBOT might actually come from HIF activation during the return to normoxia…
I think the main benefits of HBOT arise from HIF activation. I don’t think Hyperoxia has any benefits beyond that.
The influence of CO2 on up regulation of hypoxia related genes.
“ Because nasal breathing prevents hyperventilation during exercise, it promotes an increase in the partial arterial pressure of CO2. The rise in systemic CO2 stimulates hypercapnia and permits the upregulation of hypoxia-related genes.”
I thought the main use for HBOT was its potentiation of radiation(oncology) therapy, and wound (burn) healing?
AIUI it is mainly about HIF-1α
It is common practice to provide it in Korea after surgery.
Can you share more about that?
Have we discuss this piece
And/or
https://x.com/bryan_johnson/status/1902044120807567436?s=46&t=zJMJ1xVdRJYEDYz-DHipTw
Thank you for the question. I dislike sending out the wrong information. Dr Erfati serves as Chair of Aviv’s Medical Advisory Board and is the founder of and closely involved in the operations of Aviv Clinics, which offer advanced HBOT protocols. But now, when I look at it again I can’t find information that he is investing his own money in clinics.
Hyperbaric Centers - Hyperbaric Oxygen Therapy near me
Summery: Dr. Efrati has helped establish and direct clinics that offer these therapies,
I enjoyed this basic and optimistic video from the aviv Longevity Symposium. Maybe not much new information for a biohacker, but he is good at presenting advanced therapies to the public in an understandable way, and he threw in some perspective and comments that I enjoyed.
Dr. Michael Roizen, Chief Wellness Officer Emeritus at Cleveland Clinic. Founding Chair of the Wellness Institute at Cleveland Clinic and Auther of the book “The Great Age Reboot”.