Hyperbaric Oxygen Therapy is the most powerful Anti Aging measure you can take according to Bryan Johnson

[Connie_Theron_Beidel]

Please read this. Anyone interested must understand that a very specific protocol must be followed to avoid negative consequences.

[dicarlo2]

Long discussion that includes some details on HBOT mechanisms re: hyperoxia-hypoxia paradox here Oxygen, hypoxia and hyperoxia

IIRC the consensus in that thread was that HIF was likely not induced with typical (m)HBOT protocols and the benefits must be due to some other mechanism. Eg hyperoxia/hyperpenetration of low oxygen/injured tissues. HIF seems to have a fairly narrow window of activation

[John_Hemming]

@dicarlo2

IIRC the consensus in that thread was that HIF was likely not induced with typical (m)HBOT protocols and the benefits must be due to some other mechanism. Eg hyperoxia/hyperpenetration of low oxygen/injured tissues. HIF seems to have a fairly narrow window of activation

If that were the consensus, it is not a consensus I agree with.

I think the positive effects from HBOT relate mainly to the stimulation of HIF 1 α

[dicarlo2]

Fair. Here is one of the posts I was referring to.

Oxygen, hypoxia and hyperoxia

Here’s what the “experts” think @John_Hemming: Risks of perturbed oxygen homeostasis: responses and adaptations to hyperoxia and hypoxia 2025 The possibility of hyperoxia blunting hypoxic adaptations also raises questions regarding intermittent hypoxia‒hyperoxia conditioning. This method has recently been suggested to be superior to hypoxia conditioning by itself,5 but the molecular and functional/clinical outcomes have not been sufficiently investigated in appropriate (placebo-controlled) trials. In general, the dose of applied hyperoxia most likely determines its risk. While the moderate hyperoxia (often 30–34% oxygen, for a few minutes between several bouts of moderate hypoxia) used in intermittent hypoxia‒hyperoxia conditioning likely does not interfere with hypoxia adaptations (although this remains to be experimentally confirmed), 80–100% oxygen – especially if administered repeatedly for more than 10–15 minutes or continuously for several hours or longer – probably does.

[John_Hemming]

I looked at a lot of papers a few years ago and wrote this

The Hypoxia Inducible Factor - research on stimulating this

[Olafurpall]

I haven’t looked into whether or how much of the benefits of HBOT therapy would be explained by hypoxia, but we know from a lot of studies that do not use oxygen breaks that hypoxia is unlikely to be necessary for majority of the benefits. I guess people interested in aging benefits and looking at the Efrati studies are just wanting oxygen breaks to copy his protocol exactly, just in case the oxygen breaks are required for the benefits.

[John_Hemming]

There is obviously an oxygen break at the end of the hyperbaric session.

[Olafurpall]

Good point. That would be one long break at the end of the session compared to 3 short breaks and one long one during a 90 minute session using the Efrati protocol. So four times fewer breaks. is that enough to get close to the hypoxic benefits of the Efrati protocol? I don’t know.