Hydroxychloroquine and Rapamycin Interaction

I’m looking at drug interactions on Sirolimus: Uses, Interactions, Mechanism of Action | DrugBank Online and it reports “The risk or severity of adverse effects can be increased when Sirolimus is combined with Hydroxychloroquine.” But I’ve not managed to find more information online. Is any one else able to expand on this so I can better understand the risk of taking rapamycin if I someone is already on hydroxychloroquine.