This is interesting! My skin is as dry as the Sahara. For the first time, I just ordered hyaluronic acid in pill form to see if I could moisturize from the inside out.
Is that the effect it had on your skin? Or did you mean something else when you said it helped smooth your skin? (Aside from dehydration, my skin is pretty good).
I imagine you got this from his fullscript store!
@Joseph_Lavelle any comments on tremella ?
Fullscript is correct. I am a little busy and just didnāt have time to look it up.
All the rough areas become smooth. Itās crazy how fast it works. Iām interested in finding out how it works on other people. Most of my problems seem to come from my skin being so thin and that seems to cause wrinkles too. Thereās no plump. This seems to help noticeably.
Black Friday has arrivedfor the NIRA laser
Thanks, I thought Iād been cleaning up senescent cells with Rapamycin. Iāve been taking it for over 2 years and generally feel fantastic, except for my worsening hands. Will you do this FOXO experiment with or without Rapa?
Re tests, yes Iām Canadian too but planning to get some tests, including Rapamycin levels, done in San Diego when I visit there soon. If anyone has a lab to recommend, let me know. Labcorp had a heckuva time dealing with my lack of US address even though I used my sonās.
While Rap does have senolytic properties and inhibits SASP, I do not think it is the best nor the most effective senolytic.
I will continue to do our Rapa cycle as we introduce FOXO4-DRI. My approach is to maintain my baseline. Our baseline currently includes a lot of things so I like to leave that āas isā when I add or try something new unless there is a conflicting issue.
I have not read enough to fully understand how effective Rap is nor what the effective dose is for it to act effectively on senescent cells. When it comes to senolytics, dose often critical. For example Quercetin is not a senolytic at low does. What is a low dose of Q? under 2000 to 3000mg itās not very good at all forthat purpose but itās beneficial at low 500mg doses for other things.
Rapa is more of an inhibitor of senescence. But again, at what dose? and in humans or mice?
AI Overview
Yes, rapamycin has senolytic-like properties:
Rapamycin can suppress senescence and the senescence-associated secretory phenotype (SASP).
Rapamycin can inhibit cellular senescence in multiple cell types, including fibroblasts.
Rapamycin can delay entry into senescence in cells treated with chemical stress, ionizing radiation, and other factors.
Rapamycin can reduce senescent cell subpopulations.
Here is an article by Mikhail V Blagosklonny whom most of us taking Rap are aware of.
It is working amazing for me. 30 days in 
Crapā¦ If @Walter_Brown and @Bicep say something is goodā¦ That means l will be getting another supplement.
Iāll placing an order with them today and canāt wait to try this. TY! Iāll let you know.
Darn, wish I hadnāt ordered the hyaluronic acid, but Iām committed now!
Has anyone tried using microneedling (derma) rollers at home? What results have you seen, especially when it comes to wrinkles and expression lines?