How to Reverse Skin Aging (2025)

Hey man his heart is in the right place, until gene therapies relocate it.

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I was in the UK trials for isotretinoin in about 1980. Was incredible result for my acne.

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Sorry, to clarify, I wasn’t saying Bryan is doing everything right or that we should copy him. That part was in response to your “I don’t understand why folks…” statement.

I do agree that it’s a harsh drug, and I wouldn’t use it for anti-aging myself.

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His heart maybe. His head definitely not.

And what were the results?

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Considering doing a low dose isotretinoin for a while for anti-aging effects on skin. Maybe 5mg a night.

Oral isotretinoin as part of the treatment of cutaneous aging

“All patients treated with oral isotretinoin noted improvement in wrinkles, thickness and color of the skin, size of pores, skin elasticity, tone, and reduction in pigmented lesions and mottled hyperpigmentation. A statistically significant difference was found in the improvement of group A (Wilcoxon test <0.01). Using minimal amounts of this drug, the side effects were practically negligible.”

Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability

“According to histological analysis, 65% of the patients revealed alteration in the distribution and thickness of the elastic fibers, which can be interpreted as a histological improvement, while 60% showed an increase in collagen density. We observed an increase in collagen density, from 51.2% to 57.4%, (p=0.004). At the end of the 12-week follow-up period, this density decreased to 54.7% (p=0.050). There was an increase in the density of elastic fibers, from 26.5% to 31.3%, (p=0.02), which had dropped to 27.5% at the end of the 12-week follow-up period.”

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A post was split to a new topic: Pterostilbene-based anti-aging cream greatly improved skin firmness, elasticity, and wrinkle reduction