I agree 100% with your concern with the kitchen sink approach used in topical skin care products.
That is why I’m making my own topical for micro needling and DEP.
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Talking about injecting “those things” through skin barrier - yesterday tried Korean serum (approved by AI for DEP) on my face. Today have been having annoying headache since morning and some puffiness under eyes. Coincidence? Could be but I rarely have headaches or puffiness. Won’t try the serum again.
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Keep us posted on what you make and how it goes?
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Hi Lara, I really don’t know, but it’s possible. This a fundamental issue with any sort of cosmetic product. The active ingredient is also accompanied by a bunch of other chemicals to enhance the stability, make the texture nice, maybe also improve the smell or colour. The “serum” products should be simpler with less ingredients, but they still need solubilising agents etc. The products are designed to be well tolerated when applied to the skin. Once you’re pushing it through the epidermis and it has access to the dermis (and thus also blood vessels and systemic circulation), who knows.
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Yes, this. Which is why I much prefer to mix my own when possible. I can control for quality, and I’m willing to re-mix often enough that preservatives are less/not necessary. Can we start a thread for DIY serums?
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Sure - you can start new threads whenever you want!
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I’d be interested in this. Curious where you buy the peptides, and if it’s possible to QC them
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Evidence of oral isotretinoin (Accutane) increasing collagen, but possibly decreasing “elastic fibres”:
“Skin biopsies were performed before and after the end of therapy, and the various sections were submitted to specific staining for collagen and elastic fibres. To analyse the changes, morphometric studies were performed, and the results obtained were analysed by Student’s t-test (paired and non-paired). Clinical results of therapy regarding texture, colouring and aspect of the wrinkles were assessed by both physician and patient. The increase in the amount of collagen fibres was statistically significant with both dosage regimens (mean, 37.8%, increasing to 44.4%; P = 0.029 with the 10-mg dosage; and mean, 36.6%, increasing to 41.9%; P = 0.01 with the 20-mg dosage). A pattern pointing toward a decrease in the number of elastic fibres was found (mean, 15.3-12%; P = 0.014 with the 10-mg dosage; mean, 15.5-14%; P = 0.125 with the 20-mg dosage). Additionally, there was improvement in the general aspect of the skin, regarding texture, wrinkles depth and skin coloration. Despite ethical considerations, a lack of a control group using placebo may render the results less accurate. Low dosages of oral isotretinoin seem to be an effective therapeutic option for cutaneous photoaging.” - Oral isotretinoin in photoaging: Clinical and histopathological evidence of efficacy of an off-label indication https://www.researchgate.net/publication/23276635_Oral_isotretinoin_in_photoaging_Clinical_and_histopathological_evidence_of_efficacy_of_an_off-label_indication#:~:text=Skin%20biopsies%20were%20performed%20before,therapeutic%20option%20for%20cutaneous%20photoaging.
Just don’t do oral tret. Like, never. I don’t understand why folks are like moths to the flame on this one. It’s horrid.
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You mean the skin cream that people use? I’d never do that. But accutane is oral.
Bryan Johnson has used low dose oral Accutane. And for people with terrible skin, it’s an absolute blessing. Yes, it’s basically the nuclear option, but my god it works. I saw my friends daughter go from teenage pizza face to glowing K-pop idol face in a few months using Accutane.
You reap the same benefits with topical tretinoin without inner toxicity. Accutane comes with warnings for birth defects. It’s toxic level of Vit A. I use and abuse 0.1% tret— it’s amazing and $2 / tube.
Reminds me of Dr. Ellie’s take on fluoride: good for topical application to the teeth, but why on earth drink it with your water?
Yes unless someone is plagued by uncontrollable pizza-face acne, zero reason to consider taking it.
Bryan Johnson is a fucking moron. His oral health protocol is also barbaric, and just pats himself on the back based on praise he extorted from some dental hygienist. But dude wears veneers because his teeth are demineralized and I can well understand why. It amazes me anyone takes advice in earnest from him.
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Hey man his heart is in the right place, until gene therapies relocate it.
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I was in the UK trials for isotretinoin in about 1980. Was incredible result for my acne.
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Sorry, to clarify, I wasn’t saying Bryan is doing everything right or that we should copy him. That part was in response to your “I don’t understand why folks…” statement.
I do agree that it’s a harsh drug, and I wouldn’t use it for anti-aging myself.
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His heart maybe. His head definitely not.
And what were the results?
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Considering doing a low dose isotretinoin for a while for anti-aging effects on skin. Maybe 5mg a night.
Oral isotretinoin as part of the treatment of cutaneous aging
“All patients treated with oral isotretinoin noted improvement in wrinkles, thickness and color of the skin, size of pores, skin elasticity, tone, and reduction in pigmented lesions and mottled hyperpigmentation. A statistically significant difference was found in the improvement of group A (Wilcoxon test <0.01). Using minimal amounts of this drug, the side effects were practically negligible.”
Oral isotretinoin in photoaging: objective histological evidence of efficacy and durability
“According to histological analysis, 65% of the patients revealed alteration in the distribution and thickness of the elastic fibers, which can be interpreted as a histological improvement, while 60% showed an increase in collagen density. We observed an increase in collagen density, from 51.2% to 57.4%, (p=0.004). At the end of the 12-week follow-up period, this density decreased to 54.7% (p=0.050). There was an increase in the density of elastic fibers, from 26.5% to 31.3%, (p=0.02), which had dropped to 27.5% at the end of the 12-week follow-up period.”
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A post was split to a new topic: Pterostilbene-based anti-aging cream greatly improved skin firmness, elasticity, and wrinkle reduction