How to Reverse Skin Aging (2022 to 2024)

#518

@desertshores dont sell yourself short: for guy in his eighties living in AZ you look fantastic. An honest evaluation: I’ve been to AZ loads of times and most older people there look like dehydrated leather goods (the dryness and high-desert sun isn’t kind over the years). The long-time runners look even worse (even when in great shape).

Here in NYC (the land of ridiculously excessive fillers) I see plenty of 60 year olds who’s skin looks far worse than yours. I’d gather that the exercise and tretinoin actually work, although won’t likely make you look thirty again (which is your point). (Then again, I see plenty of 20 year olds at the beach who are habitually in the sun with skin about on par with yours, albeit darker).

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#519

I totally agree with @Ericross2. Many ppl 20-30 years younger would envy your skin. It’s amazing especially for Arizona. I hope that it’s effect of Rapamycin and other supplements, not just good genes.

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#520

Since I have taken a boatload of supplements daily for years, who knows?
My opinion however is it is primarily genes. Both my mother and father had very good skin into old age. We are mostly of Scandinavian descent.

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#521

First off, you look great for your age. How long have you been on top of your diet, health and supplement regime for? It definitely paid off.

About the injections + beauty products: Genes are a good thing, when you can optimize the good genes by not smoking, rapamycin, supplements +etc… But,for example, if someone has the best, most ideal genes yet has a terrible lifestyle (smoking, exposed to pollutants, terrible diet, no exercise etc…), those great genes will not mean anything because they will not be activated.

Same thing will cancer genes. Although someone might have a relative or parent who had cancer, if they can optimize their healthy lifestlye, supplementation + medications, then those cancer genes might never be activated.

My point is having good genes is wonderful but we still need to do things to maximize them.

Many don’t want to wait until 80 to see if they won the genetic lottery, and will not sag or wrinkle or look as good as you do. They want to prevent that from happening by injections, fillers, retinoids, topicals, cream, lasers etc…So that even if they are predisposed to terrible aging (aesthetically) at least it was somewhat mitigated.

For others, they might be extremely bothered by their neck sagginess, or lines and wrinkles. In that case, doing the injections is to restore their self-confidence. If they opt for Radiesse or other injections, and have even a 5% improvement they will be delighted as they improved their physical appearance somewhat.

What I’m trying to say is that no one wants to age, so anything they can do to improve physical appearance, that doesn’t directly harm their physical health, will probably be done.

Best regards

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#522

I realize that the vanity of people, myself included, leads them to do expensive things to their skin. In most cases, the hype just doesn’t live up to the expectations and expenses.
My observation from being married for 53 years is; the skin care products, probably thousands, my wife purchased over the decades accomplished more by the placebo effect she was experiencing than actual observational improvements that I saw.
Of course, what people choose to do with their money is their business, but I wouldn’t put skincare products very high on my priority list. (Unless there is some underlying skin condition that needs to be treated.)

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#523

Dr. Brad weighs in on reducing skin aging.

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#524

Cosmetic and histologic changes on photoaged skin were evaluated after using immunostains for Type I collagen, Type II collagen, and glycosaminoglycan (GAGS). Investigators found that the combined retinol, tripeptide, and glaucine containing cream was effective in improving signs of photoaging on the face and neck.1

The 20 study participants were 18 years and older and underwent biopsy at baseline and after 3 months of treatment. The average age of participants was 60 years and 90% were female. Patients stopped using other cosmetic products and tanning for the duration of the study.

The study cream, which consisted of 0.2% pure retinol, 2.5% tripeptide concentrate, and 5.0% glaucine complex (Tripeptide-R Neck Repair, Skinceuticals), was used for 90 days by participants in the open-label, blinded clinical trial. The cream was formulated with a hydrating retinol that was encapsulated with timed release and glaucine specifically formulated for thinner neck skin.

Reference

  1. Rao S, Goldberg D. Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin. J Cosmet Dermatol. 2023; 00: 1-4. doi:10.1111/jocd.15945
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#525

The before/after pic of the face is not very impressive. I think the before looks better than the after.

jocd15945-fig-0004-m
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One can do better with tretinoin or tazarotene.

https://onlinelibrary.wiley.com/doi/10.1111/jocd.15945

I’m skeptical of anything coming from SkinCeuticals. These are the same people charging $200 or more for 30ml of a topical L-ascorbic acid serum of dubious efficacy that you can make at home for like $2.

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#526

I didn’t see any reference to skinceuticals… did I miss it in the paper?

the authors are from this organization, and they don’t mention any commercial ties/COIs:

1Skin Laser & Surgery Specialists, A
Division of Schweiger Dermatology
Group, Hackensack, New Jersey, USA
2Icahn School of Medicine at Mt. Sinai,
New York City, New York, USA
Correspondence
David Goldberg, MD, JD, FAAD,
Schweiger Dermatology Group-Medical
Plaza, 20 Prospect Ave Suite 702,
Hackensack, NJ 07601, USA.

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#527

Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents

Aging is a complex physiological process that can be accelerated by chemical (high blood glucose levels) or physical (solar exposure) factors. It is accompanied by the accumulation of altered molecules in the human body. The accumulation of oxidatively modified and glycated proteins is associated with inflammation and the progression of chronic diseases (aging). The use of antiglycating agents is one of the recent approaches in the preventive strategy of aging and natural compounds seem to be promising candidates. Our study focused on the anti-aging effect of the flavonoid hesperetin, its glycoside hesperidin and its carbohydrate moieties rutinose and rhamnose on young and physiologically aged normal human dermal fibroblasts (NHDFs). The anti-aging activity of the test compounds was evaluated by measuring matrix metalloproteinases (MMPs) and inflammatory interleukins by ELISA. The modulation of elastase, hyaluronidase, and collagenase activity by the tested substances was evaluated spectrophotometrically by tube tests. Rutinose and rhamnose inhibited the activity of pure elastase, hyaluronidase, and collagenase. Hesperidin and hesperetin inhibited elastase and hyaluronidase activity. In skin aging models, MMP-1 and MMP-2 levels were reduced after application of all tested substances. Collagen I production was increased after the application of rhamnose and rutinose.

Full paper (Open access):

Past link / discussion regarding Hesperetin: Hesperetin promotes longevity and delays aging via activation of Cisd2

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#528

I am always curious with these as to how much these molecules are linked to HDAC inhibition. I think Rutin is an HDACi, whether Rutinose (which is prepared from Rutin) is or isn’t I don’t know.

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#529

It was in your original link.

The study cream, which consisted of 0.2% pure retinol, 2.5% tripeptide concentrate, and 5.0% glaucine complex (Tripeptide-R Neck Repair, Skinceuticals),

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#530

May I ask if there are any good ways to prevent rough pores

#531

Mesobotox shrinks pores and gives you smooth skin without affecting mimics.

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#532

4 posts were merged into an existing topic: Buy Rapamycin Online - List of Reliable Pharmacies

#533

Also called “Microbotox”, or “micro droplet botox”…

@LaraPo Is this a type of mesotheapy that you might do yourself? I have no idea as to whether you can purchase the botox easily if you wanted to do it yourself. It seems its available from the usual Indian suspects, this ad suggests 13,000 rupees, or around $160 US for 100iu.

Realself.com suggests:

Micro Botox (also called MesoBotox) refers to the technique of injecting Botox superficially, into the skin rather than into muscle. This is primarily done to tighten pores, reducing oil and making the skin appear smoother, though it may also improve the appearance of redness and flushing from rosacea. However, many doctors on RealSelf recommend other treatments, such as lasers and microneedling, instead of Micro Botox—or in addition to it—for best results.

The dilution and the number of units is the same as for traditional Botox injections, but the Botox is dispersed over a larger area. “Micro Botox is usually injected in the T-zone area and through the entire face: in the forehead, cheeks, nose, and chin area,” says Dr. Usha Rajagopal, a San Francisco plastic surgeon, in a RealSelf Q&A. Micro Botox doesn’t last as long as traditional Botox, with follow-up treatments needed within two to four months for continued effects.

Papers on the topic:

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#536

Yes, it’s something that is easy to do at home. However, 100 iu is a big quantity enough for several people. Once opened, has to be used immediately. There are many meso cocktails, vitamins + Botox, mixed together, that are quite popular. And you don’t need to buy such big quantity.

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#537

Yes, 100 iu is probably enough for two completely frozen faces. For mesobotox you greatly dilute botox, so I believe 10 iu are enough for pores.
Botox once prepared needs to be used immediately or refrigerated for up to several weeks, but it will loose some potency…

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#538

Interesting… it seems 50iu at $120US is the minimum size container sold (from a cursory search on Indiamart).

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#539

Doctors usually prepare botox and use it for several patients in a row… it needs to be used in hours.

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