How to reduce/prevent age acceleration from long flights or sleep deprivation

#1

Bryan Johnson reported significant age acceleration…
(and this definitely affects whether or not it’s worth going to Japan)

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I wonder if NACET, melatonin megadoses, or even 40Hz tACS can help

or GP Q on X: "“🚨 Mind-Blowing 2025 Discovery: A Gentle Face/Neck Massage Could Flush Toxins from Your Brain & Fight Aging! (Mice Study Doubles CSF Flow – Humans Next?) 😲🧠 The breakthrough study from 2025 (published June 4 in Nature) shows that gentle mechanical stimulation of lymphatic https://t.co/i7a2tuoJY0" / X

[note: the age-accelerating flight effects could just be Bryan Johnson, some people do surprisingly well with jet-lag, and a few even benefit from the disruption, just like how sleep deprivation can reduce depression in some people]

it would be nice to see which portion of the age acceleration is inflammation-related

but like, GET BLOOD TESTING OF NFL before and after

Idk, also the comfort of the seats really matters. If NYC=>Tokyo could be as comfortable as Air France…

#2

Narcolepsy Rx medication, and probably 2 different medicines: 1 for sleep, 1 for daytime.

#3

High dose melatonin at night. High dose glycine and NAC or NACET. High dose vitamin C. Avoid abusing caffeine to push through long drives, probably a shorter acting stimulant is better than a coffee after 4pm.

Try to not eat close to bed time.

Flying or where transport is covered by someone else is different. Blackout mask, ear plugs and the above sleep/recovery supplements still advised.

Strategic melatonin use once you’ve arrived in target timezone to reset circadian.