So, it turns out that 23andme shows that I have presumably higher risk of AMD (the only disease I really have higher genetic risk for)
And my nucleus genome reports shows those SNP, but also shows protective variants (so I might have a tendency to get hard drusen deposits earlier than average, but without those causing significantly increased risk of AMD)…
Anyways, what are some ways? Does reducing LDL in general help?
===
Your file (summarized earlier) fits this:
Predisposes to forming small drusen
- CFH Y402H (C/T) + CFH rs10737680 (A/A) and CFB/C2 rs429608 (G/G) → hotter complement amplifier loop at Bruch’s membrane ⇒ easier to make and keep sub‑RPE deposits.
- ARMS2 A69S (G/T) → mild ECM remodeling bias that can raise deposit tendency and (in some people) RPD risk over time.
Offsets progression risk
- LIPC rs920915 (G/G) → generally protective; skews toward small hard drusen rather than large, soft, confluent drusen.
- VEGFA rs943080 (C/C) → protective for neovascular/wet AMD features.
- CFI rs4698775 (T/T) → no added deficit in the complement “brake.”