Constant molecular aging rates vs. the exponential acceleration of mortality
Laëtitia Gorisse, Philippe Gillery, and their coworkers (1) at the University of Reims elegantly document carbamylation as a biochemical change of aging in long-lived proteins that accumulates progressively across the life span. In human skin samples, the main carbamylation product, homocitruline (HCit), shows intriguing linear increases across the life span, with faster accumulation in two shorter lived species. Carbamylation thus joins other markers of protein oxidation and DNA methylation that accumulate at constant rates throughout the adult life span.
https://www.pnas.org/doi/10.1073/pnas.1524017113
In human skin samples, the main carbamylation product, homocitruline (HCit), shows intriguing linear increases across the life span