By Alex Zhavoronkov, founder and CEO of Insilico Medicine (more on them: https://www.fiercebiotech.com/biotech/lilly-signs-275b-partnership-insilicos-ai-engine-pursuit-oral-therapeutics ): How Much Can You Extend Your Life with Drugs?
Visual summary:
This is where it gets personal. I asked each model: if you had a healthy, well-optimized, exercising 50-year-old male — what are the top 10 drugs, and what happens if he takes them all in a perfectly optimized protocol?
Every model included rapamycin, statins, metformin, an SGLT2 inhibitor, a GLP-1 agonist, and an ARB/ACEi. Most included acarbose, aspirin, and some form of NAD+ precursor or hormonal optimization. Rapamycin was the only drug that most models credited with any maximum lifespan extension potential.