What about 5 or 10mg?
Ideally one should use the least
Tirzepatide for instance, I don’t want to inject 10ml for each 5mg of it
Depends on how much you’re going to inject for each dose.
The more water, the more accurately you can dose because if your syringe draw isn’t perfectly accurate (and it won’t be) the more diluted solution results in less dosing error. Also, you’ll have less waste left over when the vial gets low. (Though you can always put more water in the nearly empty vial.)
A typical vial will hold 3mL of water. Most people will fill one with 2-3mL depending on dosing.
I wouldn’t go over 1mL subq at any injection site because of the lump (but you can gently rub it in).
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It’s not recommended to do large subq injections, large would be over 1ml. You can safely do up to a 3ml subq injection but it’s not something that should be done on a regular basis.
Then the desired dose is to be determined. Here is an example of dose progression with tirzepatide for diabetics
- 2.5mg - starting dose - in 50 units = 0.50ml
- 5.0mg progression type dose - 50 units = 0.50ml
- 7.5mg if response is to above dose is low - 50 units = 0.50ml
Can progress to as high as 15mg per dose for low responders but still at the same volume of 50units = 0.50ml
Note that the dose increased but the volume of the injection measured in units or ml does not.
To set up #1 for a 4 dose vial -
10mg TZ peptide in vial + 2.0ml bac water = 4 doses of 2.5mg at a volume of 50 unit’s 0.50ml (0.5ml x 4 = 2.0ml)
The amount of bac water does not change, only the peptide amount.
For the various peptides we use, the volume varies. From 10 units - 0.10ml with 100mcg of gonadorelin, a very tiny dose and volume.
To
50 units - 0.50ml with 3.0mg of tirzepatide.
AgentSmith has provided a link to a peptide calculator. There are quite a few out there and they are helpful for those getting started on the peptide journey.
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What peptide are we talking about, and I’m curious where you obtained 50 mg?
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There isn’t a generic response; each peptide will have a different solubility. There are items where 100 mg in 1 mL is okay, there are others where you might get solubility issues at 10 mg/mL.
Getting a reliable source for the given peptide for dilution is important. Other factors also relate to dose. If you have a desired dose of 50 mcg/dose, getting a concentration that easily works for your desire dose. For example, if you put 5 mg/mL dilution, that would be pretty hard to dose the 1 unit (0.01 mL) for that dose. You might dilute it to 500 mcg/mL and then have 10 units (0.10 mL).
There are number of factors. Going too dilute isn’t a problem generally, apart from keeping the SC dosing <1 mL per injection.
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Good question, that piqued my curiosity as well.
If one were using tirzepatide at the max weekly dose of 15mg, you could have a vial with 60mg (4 doses) of the peptide powder prior to reconstitution.
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I was guessing SS-31, but I do have a bunch of 50mg TZ vials.
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