It is said that curcumin can reduce the bioavailability of rapamycin, and there seem to be a lot of people taking them，what question has been bothering me is： to avoid interference of curcumin with rapamycin, how long should the interval be when taking them?
Hi - welcome to the site.
I’d recommend you read up on this (see paper below) but my quick look suggests that you don’t want to take cucumin the day you take rapamycin - so perhaps stop taking it (if you’re taking it most days) the day prior. Two days if you want to be more safe. Peak blood levels look to be at the 1 to 2 hour period. The half life of Curcumin in the blood seems to be around 6 or 7 hours; so every six or 7 hours after it reaches the peak blood level it decreases by 50%.
See: https://www.sciencedirect.com/science/article/pii/S0022316622002541
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I have tended to take curcumin 2 hours after rapamycin (and 22 hours before). I do see clear effects from rapamycin, but I don’t know if they would be greater if I did not take the curcumin. Logically, however, I should drop back my rapamycin dosing if trying this out as my current dosing is on the high side. I also eat grapefruit/pomelo/pomegranate and that will overcomplicate things.
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Thx for your reply! I see that the half-life of rapamycin is estimate 62 hours. Does this mean that curcumin should be avoided within 124 hours after taking rapamycin …?
The curcumin, as I understand it, affects the absorption of the rapamycin via the small intestine. So the issue is that you don’t want the curcumin in the small intesting at the same time you’re taking rapamycin.
If you take the curcumin some hours after ingesting the rapamycin I believe you are in the clear (no issues) because the rapamycin is already going through the small intestine and being taken up into the blood.
So - I would avoid taking curcumin the day prior to taking rapamycin, and then only take it a few hours after taking the rapamycin.
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I think you are right about the absorption, but there may be a serum half life issue as well. To be honest the only way of working out what happens with all the interventions I take is to measure it.
Interestingly today I had to tighten my belt to stop my trousers falling down. Because I have not really changed my diet last week and in fact have been perhaps a bit excessive if anything it seems that the large dose of rapamycin on the Monday has caused an accelerated metabolism in some way. (or at least one which demands more energy).
I measure my weight also quite frequently and accurately. That points to a 1kg+ weight loss. I bought a weighing machine which is used for weighing martial artists for contests. It gives the same result every time you stand on it if your mass has not changed.
Domestic machines tend to lie a bit to conceal their inaccuracy.
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