Hi Maveric78
Thank you very much for the links.
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Hey phil, since youāre at 8mg does this mean you have been taken it roughly 2 months?
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I suspect that Brian Kennedy is paid handsomely by Rejuvant. The clinical trials for their supplements have been successful. But he never fails to mention the placebo effect when he discusses the clinical trials for Rejuvant. He says that if you pay a lot of money for a supplement thinking that it will make you feel better, you likely will feel better!
Two years ago my main complaint when I went for my physical was always feeling tired. My physician said that is because youāre getting old. I canāt remember the last time I have felt tired. All of my measurables from bloodwork to blood pressure have improved significantly. Much of the improvements came from long-term fasting before I started rapamycin but there is some overlap between those two interventions.
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Many of those on this site respect the work of Dr. Matt Kaeberleinā¦ one of the foremost authorities on rapamycin research.
Here with Peter Attia, Matt discusses his use of rapamycin for 8 weeks that created physiological changes. And, it was not placebo.
Go to 1: 27 :10
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Yes, and Matt himself says, 'the placebo effect is very realā¦ ā
Iām not saying that rapamycin doesnāt have these beneficial effects, Iām saying that without DATA itās just anecdote and therefore worthless from a scientific perspective.
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The parabiosis clinical trial sounds interesting! Can you share any details?
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Yup! I started at 1mg and am increasing by 1mg every week. Iāll probably keep it at 10mg long-term, if only because the medication comes in packs of 10. But Iām open to changing the dosage if I see good advice/data in this forum!
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Letās not exaggerate. No one has said any such thing about their dog. I wrote about the glasses and Iām sorry you disapprove.
For those who are intellectually curious and not inclined to dismiss peopleās first hand accounts out of hand, I had not needed reading glasses for 20 years since grad school when last year, around age 47, I began to need the glasses to read my phone.
I used them for 6-8 months when I began rapamycin. Since then I have stopped using the glasses and stopped needing them.
Placebo? Maybe. Coincidence? Perhaps. Iām certainly making no claims about causation, because how can you know?
What I know is that I needed reading glasses and now I donāt. Thatās the data.
For the record, a persistent shoulder pain (3 years) disappeared in my 2nd to 3rd week of rapamycin, when Iād started with 1mg and took 2mg on week two. The shoulder never hurts now. More data.
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Lots of info in this thread: Plasmapheresis Startup Looking for Clinical Trial Participants SF Bay Area
Its all been pretty uneventful so far. Iāve gone in for 4 parabiosis sessions so far, two more to go next month. You go in, lie down, they put the large needles with hoses into your arm veins (one on each arm, one taking out, one putting back in), and you sit there for three hours while the equipment does its work. I bring my headset and prepare my podcasts, and audio books and to entertain myself.
They actually put a good amount of effort into blinding the participants from knowing whether they are getting the actual treatment or a sham treatment (they have a control group). There is a curtain barrier between the patient and the equipment, and the blood hoses are covered in a black wrapping to hide whether blood is moving through the hoses, and they cover your arms with towels too.
To be honest, Iāve not noticed much difference in anything. I havenāt done any bloodwork, etc. since starting because I want to remain unbiased (Iām assuming that I would notice some changes in my blood work and biological age if I was getting the treatment). But so far, my guess is that Iām on the control arm of the study just because Iām not feeling any difference. They do some basic functional testing - grip strength, balance, etc. every time I go in , and not much difference so far.
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Iām totally with @Maveric78 on this - we really want to try to get good data on everyoneās outcomes here. Ideally measures from devices that take the human error element out of the equation.
I mean ideally we really want large, placebo controlled clinical studies of rapamycinā¦ but that doesnāt seem likely anytime soon, so the next best thing is aggregated data from people on this forum. The more data the better. Fitbit measures, lab measures, Optometry measures, etc. Please - if you can gather pre and post data on any biological or functional measure, I encourage you to do it.
That said, Iām also interested in subjective measures too. In fact the FDA has had a major initiative that moves in this direction too, an area called āPatient Reported Outcomesā - and they put a lot of weight on this now.
My point is simply we want both. Right now I think weāre probably weaker on the hardcore data, so I encourage people to do pre and post testing (as much as possible, as many parameters as possible) and post the data here.
Details here on the FDAās move towards PROs: Focus Area: Patient-Reported Outcomes and other Clinical Outcome Assessments | FDA
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I donāt know for sure but I think that it may be the case that part of the reason why placebos seem to have an effect is that people may be making other changes in addition to taking the placebo and the other changes are actually causing the effect. This would mean that the effect of placebos is not purely psychological.
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My dog was noticeably better the day after his first dose (1/9/23) to the point of convincing my skeptical husband to consider taking rapamycin for himself. My dog has maintained his initial improvements and although his first dose was the most dramatic change he has continued to become about 10% more mobile with each passing week. I didnāt share this with any exaggeration or thoughts of misleading anyone. Iām fully aware itās anecdotal but donāt think it can be placebo with both of us noticing the same changes in our dog. I apologize if people found my report far fetched. His change seemed really rapid for us as well and I would have never believed it if I hadnāt seen it for myself.
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I find your dog report very consistent with what others with older dogs have been saying on here.
That almost immediately vision, alertness, hearing, sense of smell, and better mobility returnā¦ realizing dogs age so much faster probably the effects of healing with rapamycin in their systems is faster too.
Happy to learn these loyal companions are getting a last youthful spurt of life.
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I think this type of report is great. But Iām also wondering how we can improve on it and get some data. Iām going to be giving some rapamycin to friends to try with their dogs and Iām wondering how best to try to quantify the results (pre and post).
Iām thinking that the increase and energy would be quite well measured by some sort of doggy fitness tracker - what do you think?
Ideally Iām thinking weād put the track on the dog a few weeks prior to initiating rapamycin to get a baseline of activity, sleep, etcā¦
Any other ideas out there on how to get data from these dog rapamycin trials?
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Today Michael Lustgarten, Ph.D., discussed albumen as the most important marker on the various age tests.
Since taking rapamycin for over a year my levels have increased from 40 to 43 and seem to be trending upward. This is the first biomarker in which I have seen improvement since taking rapamycin.
āOf 41 biomarkers included in Aging.aiās platform, serum albumin has the greatest relative importance.ā
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A doggie fitness tracker would have picked up the dramatic improvement that my dog experienced almost immediately upon taking Rapamycin.
She had been parked on the couch for perhaps 90% of the day beforehand.
After dosage she was up and moving, lying on the couch perhaps 60% of the day. She was more social with us, more hungry, and more playful with other dogs.
Like the poster said above, it was a surprising and immediate change.
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We have another dog that will be 3 at the end of April. My husband mentioned starting her on it at some point but I think right now might be a tad too soon? I will definitely get a tracker for her and follow your suggestions before starting her on rapamycin though. Thanks!
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The mouse rapamycin studies showed the greatest lifespan increases when they started the mice at 9 months (early adulthood), equivalent to 25 years or so in humans. So I started my dog at age 3 years on rapamycin, which is āroughlyā the same age equivalence. No problems, but hard to identify benefits at this age also.
I havenāt done the doggy fitbit ā¦ but wish I had.
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Blsm, how old was your dog that had the dramatic improvement? Sorry if it was mentioned before but I didnāt catch it.
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I should have a full set of pre and post data by the end of this month to report (Iāll add it to the thread where I put all the pre data).
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