How does rapamycin affect BUN? (it increases with age)

Liver and kidney functions were also normal based on ALT, AST, total bilirubin, total protein, albumin, creatinine, and BUN (Figures 1B, S1A, and S1B). Among these, albumin decreased and BUN increased with age (within the healthy range) demonstrating age-associated effects on renal systems consistent with previous reports.14,15 Well-described age-associated changes were seen in red blood cell count and hemoglobin,16 which all decrease with age

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I think that you can look at the BUN trend line over many many measurements, but mine varies significantly from measurement to measurement based on my protein intake. I see no correlation with my rapamycin intake. There may be one, but I do not see it.


Rapamycin increases my creatinine and BUN. If I do bloodwork when I’m on a week break from Rapamycin all my biomarkers are better and especially those on my renal panel. It may not translate well to those who don’t have a transplanted kidney.

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