WoW!!
Your advice on being active during the healing process is spot on.
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How will you be sure you don’t have cancerous cells in your body right now? Are you sure that by increasing angiogenesis you won’t fuel their growth before the tumor immunosurveillance is able to detect and neutralize these cells?
I am providing a counterargument to your advice of taking large amounts of these compounds on chronic basis. I personally would not without robust human data. Using it for a limited time after injury makes more sense and would limit potential risk.
While there is no single, universally cited number for how many undetectable tumors an “average” person has, scientific studies suggest that the vast majority of people—particularly as they age—harbor dormant, microscopic, or indolent tumors that never cause illness.
Here are key insights based on autopsy studies and cancer research:
- Autopsy Findings (High Prevalence): Studies on individuals who died of other causes have shown an surprisingly high prevalence of hidden cancers. For example, some studies found that nearly 100% of individuals between 50 and 70 years old had microscopic, indolent (inactive) cancers in their thyroid glands, even though the clinical incidence is very low.
- Breast Cancer: Postmortem examinations have shown that approximately 39% of women in their 40s harbor microscopic, undetected breast cancers, despite the clinical incidence of breast cancer in this age range being only about 1%.
- Prostate Cancer: Similarly, autopsy studies indicate that about one in three men in their 40s-50s has microscopic prostate cancer, a number that increases with age.
- “Dormant” State: Many of these tumors remain in a dormant, non-angiogenic state (not growing new blood vessels) and can remain in the body for decades without progressing.
- Immune System Control: The human body generally has a robust immune system that identifies and destroys or limits these abnormal cells, preventing them from becoming harmful.
Conclusion: It is highly likely that an average, asymptomatic adult has at least one, if not several, microscopic, dormant, or slow-growing tumors that are not detected by current medical screenings.
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Looks like a lot of beneficial stuff increase VEGF.
BTW I do them all except Hypoxic Training and HBOT.
Interventions increasing Vascular Endothelial Growth Factor (VEGF) which signals the body to build more blood vessels:
- Lower-Limb Resistance Training (RT): High-intensity lower-limb RT is often the most effective method for increasing VEGF in healthy adults. Dose benefits appear above 600 METs-min/week and peak around 1950 METs-min/week.
- Blood Flow Restriction (BFR): Combining low-load resistance exercise with BFR creates a hypoxic environment that stabilizes HIF-1α, a key trigger for VEGF transcription. It is significantly more effective at boosting VEGF mRNA levels than exercise without restriction.
- Hypoxic Training: For specific groups, such as those with obesity, combining aerobic and resistance training under hypoxic conditions (e.g., altitude-simulated environments) has shown the strongest VEGF response.
- Ischaemic Training: Brief periods of blocking blood flow to a limb (either via a tourniquet or sustained isometric contraction) can stimulate VEGF.
Nutritional & Supplemental Supports
- Omega-3 Fatty Acids: Daily intake of 1–2g EPA/DHA supports VEGF production and overall vascular health.
- Vitamins & Minerals: Adequate levels of Vitamin D3 (2000–5000 IU) and Zinc (15–30mg) are vital; deficiencies in these can impair VEGF function.
- Antioxidants: Compounds like Resveratrol (100–250mg) and Curcumin (500–1000mg with black pepper) help restore and promote normal VEGF signaling.
- Nitric Oxide (NO) Boosters: Foods rich in nitrates, such as beetroot juice, enhance circulation and support the downstream effects of VEGF.
Medical & Other Therapies
- Hyperbaric Oxygen Therapy (HBOT): These sessions can enhance blood vessel formation by stimulating VEGF production during the repair phase.
- Detoxification: In cases where levels are low due to environmental toxins (like mold), supporting liver function with Glutathione or NAC may help restore normal production pathways.
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That is a great question and I agree that experimenting with BPC may have a downside.
So Monday and Tuesday I’m going to do a better review of VEGF the various types of VEGF and how it may affect cancer potential with respect to the aging process.
A couple of my thoughts/questions will be,
What is VEGF and how does it work
How is VEGF produced
Is there a normal level of VEGF
As we age, what happens with VEGF - does it increase or decrease
How many types of VEGF are there,
Is there 1 or more type more closely related to supporting cancer
What are the major drivers of cancer related to age
What keeps cancer in check,
What systems that keep cancer in check fail as we age
how important is the immune system in this process
How does the immune system perform as we age
Does BPC157 increase VEGF and which types
Is the amount of VEGF created in this process quantifiable
Does Thymosin Beta 4 increase VEGF
Is the amount of VEGF created in this process quantifiable
I have a few more questions rolling around in my head on this topic
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I’ve larned a bit here 
I had read quite a few of these studies a couple years ago but with Perplexity we are able to put all that info into a more readable format. This attached PDF would have taken me weeks to put together. My analysis would have been very crude and simplistic. Now, a deep dive can be done in less than 2 hours.
VEGF is basically an on-demand system with low basal levels, that increases production based on stress type inputs.
The dose levels (500mcg + 500mcg) of what we take do not induce excess VEGF production, more like an enabler/enhancer of the age related decline in the demand system, BUT this enablement of the system would be an issue with active cancer, which would typically be treated with VEGF suppressors when it was detected.
So DrBart’s point remains unresolved, we all have cancer in us that is being dealt with, mostly by our immune system. A system that is weakening as we age, while most are doing nothing to support or improve it. Conversely some of us are ware of the importance of the immune system and are actively doing what we can to improve it.
Having a more youthful VEGF system may also have benefits.
Plus some in vivo tests indicate cancer inhibiting aspects of these 2 peptides but I would not bank on that as other things we can do have more proof.
For my personal use, I’m not as concerned now as I was when @Dr.Bart brought up the important question on VEGF increase from BPC 157 + TB500 (I use the full TB4 aa43 version) For several reasons,
- Cancer does not run in my family - one of the more important aspects of cancer.
- I don’t drink or smoke
- I’m at my ideal weight
- My diet while not perfect is keeping me strong and healthy
- I’m physically active
- My glucose is well controlled
- I support my immune system (TRIIM) and those markers are all good.
- My inflammation is very low, Lifestyle and interventions with peptides, BPC + TB4 reduce inflammation plus several other peptides I use do that as well.
- I get all my vaccines
- I pass my PSA test every couple of years.
- I pass my stool test every year.
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Bodybuilders have been using BPC157 since around 2012 and there is no cancer epidemic in that community
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Without pre-registration hard to tell if it’s simply survivorship bias.
I would say unlikely. We hear constantly about heart and kidney related deaths among them. Cancer we really don’t hear about that often. One possible theory is that IF there is any cancer risk for BPC157, it is being offset by constant resistance training, which is extremely cancer protective.
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I used the Wolverine stack (combo BP-157/TB-500) over several months injected sq to the area of my high grade gluteal medius tendon tear. I was also receiving PRP injections. The pain of this tear was intolerable. My orthopedist claimed PRP would take 3-4 months to work. I started to inject the peptide combo soon after PRP. Within 1 month I was dramatically better. 3 months later I did a 2nd PRP injection and my orthopedist was stunned at how quickly I was recovering (he did not know about the peptides as he is not on board). He said he never normally gets these results with a high grade tear. In any case, I truly believe this combo has helped heal my acute injury. Just an anecdotal report, N=1.
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It seems like everyone I meet is taking BPC157. A woman I just met on an elevator told me she started it the other day because her shoulder has been hurting lately.
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