That post covers many areas… and it’s complex, so this could be a very long discussion.
My take is that you want to first look at the major reasons people die prematurely - then work back from that…
What Are the 10 Leading Causes of Death in the United States?
- Heart disease.
- Cancer.
- COVID-19.
- Accidents.
- Stroke.
- Chronic lower respiratory diseases.
- Alzheimer’s disease.
- Diabetes.
Source: 10 Leading Causes of Death in the United States
With that as a backdrop (the most likely things to kill you), then look at the the link you posted. More calories and nutrition mean higher activation of mTORC1… and we know that results in shorter lifespans (because rapamycin blocks mTORC1 and increases lifespan in every organism tested by about 15% to 30%.
But - as you suggested, there are also benefits to higher metabolism - better muscle growth and tissue regeneration, healing, growth, etc. So mTORC1 activation is absolutely helpful in many cases.
So - you need both for a good life. The key is to modulate it in a way that optimizes your health and longevity over the long term. The issue is that as you get older mTORC1 tends to get stuck on “active” mode, and we know that is bad, it accelerates aging. So the older you get the more you would likely benefit from periodic mTORC decreases (i.e. less food periodically, less energy, less mTORC stimulation.
On their different approach to Lipids - you’re such more likely to die of heart attack / cardio vascular disease before cardiolipin issues - so I stick with a low LDL-C / APOB approach and generally keep saturated fats low.
I also threw that text from the X post you linked to into Gemini Pro, Deep Search with the following prompt:
Using the best scientific and clinical research, Critique the two different approaches, beliefs and statements by Bryan Johnson and Ray Peat as outlined in the following text: (your X link)
Response:
The Dialectics of Bioenergetics: A Comprehensive Scientific Critique of the Johnson-Peat Dichotomy in Human Longevity and Metabolism
1.4 Conclusion on Metabolism
The dichotomy is between minimizing damage (Johnson) versus maximizing repair (Peat). Current evidence suggests that while CR reliably extends maximum lifespan in short-lived species (low entropy systems), its effect on humans is likely more impactful on healthspan(delaying the onset of metabolic disease) rather than radically extending maximum lifespan.Peat’s high-metabolic approach carries the risk of accelerating aging if the uncoupling mechanism fails or if nutrient overload occurs, leading to hyperinsulinemia rather than thermogenesis. However, it offers a compelling model for “functional aging,” preserving muscle mass, libido, and cognitive speed, which are often compromised in deep CR states.
You might be interested in the full evaluation here: https://gemini.google.com/share/426cafd9dbbd
