I have been tracking my blood glucose and shifted to 16 mg/ fortnight so the impact was less frequent.
Took bloods 2 hours after taking Rapa without GFJ and without my usual fat quota.
Trying to calibrate - this seems very high, since last time on 12 mg I only registered 11mcG/L.
Anyone else had such variability?
I normally have my rapa with a butter coffee - so wondering if this is what caused the difference since I think the fat flattens out the top and lengthens out the effect?
What time of day did you take the rapamycin in each case? Any other meals or food in the hours prior to dosing?
Both about 2 hrs before collection.
The most recent sample, I didn’t take fat with it - but didn’t have breakfast in either case.
Thinking I will go and get another blood test at 2 weeks to see how the body has gone getting rid of it. Maybe it has been building up on a 16mg/ 2 week dose…
That’s a huge variance. The fat might explain 30% of the variance but the rest… I can’t explain. If you were even 15 minutes off the 2 hour target that might explain it. Catching the peak sirolimus levels is like catching a falling knife, very difficult and rapid variations.
The trough is more important. Check levels just before next dose.
yeah - could easily be 15 minutes difference - so perhaps that plus the fat, plus it was a 33% increased dosage…still surprising that produced 4x.
Seems I caught that falling knife on the second, sample, ;$.
Agree - I’ll check I am back under 2 before I take my next dose - thx for your feedback
So it seems my trough level is fine. Took a 2 week holiday just to make sure while waiting for results, just to be sure.
Might drop back to 12mg/ fortnight and take it with fat to blunt the spike - is my conclusion. Besides the lab rang me up in a slight panic asking if I wanted to chat to a doctor on the first sample 
Anyone else done multiple peaks/ troughs in blood levels?
I keep telling people to test rapamycin at 24 or 48 hours after dosing. It’s mostly useless to test your levels a few hours after dosing. There are so many factors that influence when you experience the exact peak and how high it is so there will be a wide variation in your levels a few hours after dosing. Your results are not strange and prove my point of how much better it is to test blood levels long after the peak is over.
