HbA1C - A very deep dive into glycation genetics pathways for actionable info

I have consistently found that my HbA1C levels are disproportionately high compared to my actual glucose readings. Specifically, the estimated average glucose (eAG) is significantly higher than my measured average.
I have already pointed to the limitations of the rather (very) bad eAG study but I still think my HbA1C is higher than expected from the glucose.

That’s why I am now examining glycation independently from glucose regulation. I previously analyzed glucose regulation in detail here: A comprehensive and very deep dive into glucose dysregulation - Pathophysiology, Diagnosis, Medications, Genetics, etc

Because I found the insights from that glucose regulation genetic analysis so interesting and actionable, I have decided to skip a detailed description of various glycation pathways and move directly into analyzing the genetics of glycation.

So here it is:
Glycation_Pathways_Genetics.pdf (85.0 KB)

Following that I analyzed my own specific genome and got that N of 1 report:

Clinical Implication: The patient’s HbA1c likely overestimates true glycemic exposure. CGM
data is a more accurate reflection of actual glucose control than HbA1c suggests. This should
be considered when making treatment decisions based on HbA1c targets.

Glycation_Pathways_Genetic_Report.pdf (202.6 KB)

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Nice unpacking. I don’t follow all of the Tx but I get the directionality.