Hazel Szeto, SS-31 peptide, the World's First FDA-Approved Mitochondria-targeted Drug (Longevity Summit, 2025)

There are lots of problems with crypto, but the transactional costs are much higher than the banking system.

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Bitcoin is terrible for buying drugs: network is too slow, fees are too high, and it’s too volatile.

Cheapest network is still Solana. Cheapest way to buy crypto is still to buy PYUSD on paypal, send to your Solana address, and optionally swap for your vendor’s preferred stablecoin. Takes me 2-3 minutes to do the above when I’m ready to buy. The transaction cost is usually less than 0.1 cents.

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Just reporting: setup Kracken Pro, funded from bank acct ACH $500. $500 arrived instantly. Bought $500 of solana, got $498 worth of Solana. Dug for the fee: $1.78. Still is 3.4% fee, but beats my prior worst fee paid of $96 on $1000, 9.6% fee all said in Exodus via moonpay via venmo via direct from bank acct.

All these apps used the same design guide; max confusion, hide or not implement obvious things. Make actions hard to figure out. Force you to google every small todo. ;( ;( ;(

In Kracken Pro looks like to send crypto to a rremote address (some vendor) its called a Withdraw. Paste the address or scan the QR code.

Good luck, curt

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Good tip. I gave up on cash app / paypal assuming funding fees are too high. This may be a good scenario for other crypto newbies. My torturous path I can’t recomend.

tnx for posting. I’ll experiment to see my transaction costs with this path, Curt

Can you spoon-feed me a bit here.

Buy PYUSD in PayPal, got it.

Send to my solana address (I don’t think you mean exodus, so where is this being sent to exactly?)

And after it is there, then I swap PYUSD to, for example, USDC… right?

And then I send it to the vendor.

If you have an Exodus wallet, you also have a Solana address (and a ETH address, and a Tron address, etc). To find your Solana address, go to any holdings you have in Solana network on Exodus, and press the receive button. That should show your address that sou should be able to copy.

AH, eureka…

So, I buy PYSUD

I send PYSUD to my solana address within Exodus

Then once in there, I swap it to USDC… and send it out from there…

I guess I assumed if in solana, I had to, um, buy solana :).

This is great, thank you!

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The list price for the branded version of SS-31:

HFeoGo8WcAA0448

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By frozen do you mean delayed or something else? I’ve never had a problem with Coinbase. I just keep enough cash in USDC to make an occasional purchase after which I re-supply more cash to USDC. Unless required I don’t specifically convert my USDC to Bitcoin for a purchase. It’s a fairly simple process to me, but if you’ve found a better system tell me about it.

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I’ve had multiple things happen.

I had a reasonable limit on my debit carb that I linked to fund coinbase and it worked really well a couple of times… but then

And I can’t remember the order of events…

one time it just delayed moving my assets over to my wallet… maybe it was a week (calling that frozen).

Then another time it showed ApplePay was an option to fund my coinbase, so I tried that… it failed becasue you can’t use Apple Pay :), and then it effected my other limits! I can now only move $50 at a time from my linked debit card and then it will will say $0 limit for several days… and then eventually it will say $50 again…

I have since linked PayPal and that limit is $1k, but PayPal charges a fee to move money over, so that seems pointless.

GAH!

I should contact them but I assume they will be as helpful as PayPal when they have held my xfers for a week … which means not helpful

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The Branded version of $$-31…FDA* approved.

*FDA: Failure, Deception, Abuse

Given Colwyn’s response, I guess you don’t want to wait until you’re too old to start fixing your mitochondria with SS-31…

I asked Colwyn, what is your take on the potential for SS-31 to help in aging-related mitochondrial dysfunction?

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Perhaps a good example of why people shouldn’t go to TikTok for medical advice?

People Online Are Injecting This Popular Peptide to Improve Their Vision

Some are claiming the peptide has also helped their astigmatism.

Key Points

  • TikTokers are using a peptide called SS-31 for their eye health.
  • SS-31 technically has FDA approval. However, it is used for a rare mitochondrial disease. Recent research looking at SS-31 to protect the retina found the drug was ineffective.
  • As more people stay indoors and look at screens, the number of myopia (nearsightedness) cases is expected to rise.

IF YOU ARE squinting to see TikTok, you may be wondering about the peptide elamipretide (SS-31). Right now, the platform is buzzing over this peptide elamipretide and its purported effects on improving eyesight. Some people on the app have even claimed that the peptide improved their astigmatism, a common eye condition that leads to blurry vision.

“I want to see if my eyes are improving in some way on SS-31,” said one poster. “Light sensitivity—computer screen light, blue light—it seems to be less bothersome, where my eyes can actually focus on light a little bit better.”

YET DOCTORS AREN’T convinced that SS-31 lives up to the vision-changing claims. That being said, they are keeping an eye on SS-31 for a different type of eye health issue. “Elamipretide is being investigated for improvement of age-related macular degeneration (AMD), not ‘aging eyes,’” says Jeffrey J. Walline, OD, PhD, an optometrist and the associate dean for research at The Ohio State University College of Optometry.

For AMD, Dr. Walline says the drug is experimentally injected into the eye to protect the retina. This is the part inside the eye that helps you see. “An initial phase 2 investigation reported that the drug did not meet any of its endpoints, indicating the drug was ineffective,” he points out. “The follow-up study has not been completed, so no results regarding elamipretide’s effectiveness for improving vision loss secondary to AMD are available.”

While the trial is still ongoing, there are a few takeaways worth noting. One: A whopping 86 percent of people in this clinical trial had side effects. Two, people taking SS-31 to improve their eyesight weren’t injecting the peptide into their eyes.

Dr. Walline stresses that while AMD can impact your vision, it’s not the same as needing vision correction. “Elamipretide does not have anything to do with astigmatism or presbyopia, a condition when people over 40 years old have difficulty reading close print.”

Raj Maturi, MD, clinical spokesperson for the American Academy of Ophthalmology and ophthalmologist at Midwest Eye Institute, stresses that SS-31 is not an “established treatment” for common vision issues like myopia (nearsightedness), presbyopia, or astigmatism.“Those problems are optical and structural,” explains Dr. Maturi. “A mitochondrial peptide is not expected to reverse those underlying vision conditions.”

SS-31 may help slow down macular degeneration in theory, says Bavand Youssefzadeh, DO, an ophthalmologist at Global Lasik and Cateract Institute in Huntington Beach, CA. But again, the research hasn’t proven it and this is very different from issues like nearsightedness and astigmatism. “This is not a general eyesight improver,” Youssefzadeh says.

Read the full story: People Online Are Injecting This Popular Peptide to Improve Their Vision (Men’s Health)

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You’ll be the first to hear if my astigmatism goes away

Reason #1M I’m happy not to have a TikTok account.

Peter Attia’s recent take on SS-31, from his AMA:

Peptide case study—SS-31: mechanism of action, approved use in Barth syndrome, and other claimed effects [18:15]

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