Have a great longevity seekers - Rapamycin before Surgery?

I will be looking to have knee surgery soon and was wondering if i should stop rapa prior to. TKR.

Yes - most of us pause rapamycin out of an abundance of caution:

See: Rapamycin and Surgery

and: Rapamycin and Injury

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I would not say “an abundance” of caution. I would think it would be an obvious mistake to inhibit mTOR when you need wound repair and also to take the risk of inhibiting the immune system when the chances of infection are higher.

Yes - but it depends on the dose and timing. For most of us with a once weekly dose of rapamycin on day 1 is likely going to have minimal mTOR inhibition by day 4 or 5. Not that I’d risk it.

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