Are you doing dasatinib and quercetin pulses? If so have you noticed any benefits like Todd mentioned?
I donāt use dasatinib. Only quercetin, fisetin, piperlongumine,
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Yes, I saw that. Iād like to see more data since so many previous studies have shown various benefits without indication of damage.
D+Q protocol:
This, of course, is one of the dangers of polypharmacy. FOMO as a result of the theory āIf we wait, it may be too late.ā As I have posted before in various threads, young people need to be more cautious. If you are young, you probably donāt need it.
As an 85-year-old, and you may not fathom this way of thinking: I have lived a good life, and if I accidentally off myself tomorrow, it is no big deal. I have already lived past my life expectancy for people born in 1941. My main concern is to prolong my healthspan and keep my mind functioning properly until the end, lest I become a burden to others.
I donāt know what the cause of Chuck Norrisā death was, but he appeared normal in a recent social media post. Going that way is okay by me. Live long and fall off a cliff.
This is a small study, but it involves humans, not mice. Oddly, it appears that if you were taking fisetin along with D+Q, you did no harm.
Didnāt we already know this? @Rob Tuck posted this in March of '24
Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions
āIn the context of our study, the administration of senolytic drugs Dasatinib and Quercitin significantly increases biological age measured by first-generation clocks, with DNAmPhenoAge being the only second-generation clock showing an increase. Notably, there is a lack of significant changes in second and third-generation clocks such as GrimAge and DunedinPACEā
Boxplot showing the evolution of epigenetic age acceleration (EAA) first-generation clocks in the Dasatinib and Quercetin (DQ) study.
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