Has anyone tried the combo of metformin + rapamycin + SGLT2 inhibitors?

#1

Or any research tried it?

#2

INVOKAMET is supplied as film-coated tablets for oral administration. Each 50 mg/500 mg tablet and 50 mg/1,000 mg tablet contains 51 mg of canagliflozin equivalent to 50 mg canagliflozin (anhydrous) and 500 mg or 1,000 mg metformin hydrochloride. Each 150 mg/500 mg tablet and 150 mg/1,000 mg tablet contains 153 mg of canagliflozin equivalent to 150 mg canagliflozin (anhydrous) and 500 mg or 1,000 mg metformin hydrochloride.

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#3

I am switching to Synjardy XR (empagliflozin + metformin ER). I was previously on IR metformin. Weekly 6mg Rapamycin and tracking with a CGM.

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#4

I am using Farxinga (Sglt2), Metformin and rapa. My HbA1c has fallen from 5.8 to 5.6 but I don’t have a CGM to monitor over time. What do you see in you blood sugar movement with meals and exercise?

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#5

Hello Joseph. My most recent HgA1c was 5.5 on regular metformin. I can post any changes I notice, I just started. I switched for all the other organ benefits. See the picture.

sglt2 inhibitors
sglt2 inhibitors741×355 83.8 KB

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#6

This is the article the picture is from.
antioxidants SGLT2.pdf (1.7 MB)

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#7

I don’t know about any research, I haven’t had time to look into it.

As for me, I take metformin and an SGLT2 inhibitor with rapamycin.

I take immediate release metformin 425mg, and 50mg Remofloglozin before meals and 50mg acarbose and 125mg white bean extract with meals.

On the days that I take rapamycin, I take it (rapamycin) with meals and 10mg lithium.

I am ‘playing’ around with the rapamycin dose and route but everything else remains constant.

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#8

I just need some clarification. I take 25 empagliflozin and have added 2mg Rapa weekly. For the first 4 days post Rapa, my glucose is way up and my hunger is way up. -and of course i am experiencing wt gain. Is it ok to add metformin for the first 4 days? Will it affect workouts? Will I have a lactic acid issue? I could retry tirzepatide, but the side effects were not worth it for me

#9

Metformin may affect workouts but it shouldn’t affect lactic acid unless you are already predisposed to that side effect.

I take an extra dose of Metformin with my Rapa along with more of my statin.

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