Guidance for a peptide newbie? DKK1 antibody and WNT signaling

#1

Did not imagine wandering into this pond. Have been uncovering layer after layer about what is know about osteoporosis, particularly osteoporosis largely caused by genetics. Specifically: too much sclerostin inhibiting proper WNT16 signaling. WNT16 signaling declines with age and loss of estrogen. But my genetics show two SNPs (2908004 and 270466) where I am homozygous for the risk allelle that drives, per Promethease, “weaker bones”

Romusuzumab (Evinity) addresses this, but there is also a peptide that works in a similar way, reducing sclerostin effects on the impeded WNT16 pathway.

So now I am into the peptide weeds, Would appreciate guidance – anyone know anything about DKK1 and how to obtain, and use? Assume I know nothing.

#2

I wouldn’t call myself a peptide newbie. I’ve read a lot about them. This is the first I’m hearing of DKK1, so you’re not likely to ever be able to source this without a custom synthesis, which I don’t recommend for something like this.

If an already established medicine can treat your condition without having to resort to experimental options I would say this is your best course of action.

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