I’ve just ordered a red light therapy cap. Been using a panel for a little while and enjoyed it so I’ve ordered cap and mask. I think that will improve circulation in the area. I use a scalp massager a few times a week.
I’ve tried many things over the years and I’ve always felt if I ever do anything that reverses gray hair I’ve discovered something that is profoundly rejuvenating unless it’s a very specific topical formula made only to reverse gray hair.
There was the case where they were testing a new anti-lung cancer drug there were consistent numbers of patients getting gray hair reversal. Given the information I’ve learned as of late of senescent cells I wonder if this was some kind of senolytic effect?
The drugs used were Nivolumab, Atezolizumab and Pembrolizumab. I would love to see these used in the Ora Biomedical C. Elegans studies.
As far as I can see these drugs like Nivolumab, Atezolizumab and Pembrolizumab strengthen the body’s ability to detect and destroy cancer cells. In regards to hair, what could be happening is that the body’s immune system is able to detect senescent cells in the hair follicles, destroys them and replaces them with new cells.
It is most likely that hair graying is caused by senescence, accelerated through infections, stress and general inflammation. In order to reverse the loss of pigmentation, the only way I see is powerful senolytic compounds. It would probably be good to have generally very good health and no inflammation, maybe combined with local hormesis (like microneedling).
There are at least three of us in the forum that have posted pictures of the effect of rapamycin on hair pigment and new hair growth.
No, rapamycin did not completely change my hair from silver to black, but it did change enough to be noticeable. I also believe that rapamycin restores some hair in males who have genetic male-pattern baldness (me). Rapamycin produced a significant amount of new hair. Not enough to change me from bald to a full head of hair, but I started rapamycin late in life. I think that younger people taking a significant amount of rapamycin will delay turning gray and loss of hair.
It is very subjective IMO. I haven’t seen any effect whatsoever on hair (from 2 years of Rapa use). It is not darker and it is not thicker either. Any claim that RAPA has a significant effect on hair I’d take it with a truck load grain of salt LOL. The only thing that does make a difference (pretty big one at that) is minoxidil and finasteride. Everything else I’ve tried has made no difference at all.
Wasn’t subjective. Pictures were provided. Personally I think it is dose dependent. Two of us take high doses compared to the average rapamycin user. I would like to see if any other forum members experienced this result.
One @John_Hemming has a different protocol, and his results might be due to his other supplement intake. As I said, I don’t think rapamycin totally prevents hair loss or turns all of your hair color, but it was significant enough to be noticeable.
There is a simple issue in that hair can get stronger, move from vellus to terminal and move from white to pigmented. That links IMO to improving mitochondrial efficiency.
What you guys are seeing is normal life cycles of hair. some will fall and come out black/dark color and seeing it makes one think that the hair is changing, but it is not. Even the guy that started this thread kept saying it was rapamycin and then few months later he mentions that he’s using minoxidil and some other stuff. If you want to be subjective, put a picture of yourself before you started rapa side by side a current picture and I am almost certain that the change will either be unnoticeable or if anything your hair currently will look worse/thinner than the picture from 3-5 years ago (as result of natural aging).
IMO Rapamycin will not affect your hair for better or worse in any significant way. I can venture to say that my hair looked a bit thinner/worse because of Rapa, but then again, we are getting older (not younger LOL) so obviously it must’ve been because of the aging process. But I am 100% certain that rapa did not make any positive difference on my hair. I do however think that I have less pain and joint discomfort because of Rapa.
What has helped me with hair (maybe a bit darker, but definitely much thicker) is finasteride and minoxidil. Nothing else that I tried made a difference.
I have previously expressed my skepticism. I don’t think rapamycin cures baldness or restores hair color to any great extent. Personally, there are too many confounding factors. I dramatically expanded my supplement list after joining the forum and seeing various studies and recommendations. Even though polypharmacy, including rapamycin, continues to increase my hair density and color. I won’t be taking my hat off in public anytime soon.
Unfortunately, I wasn’t taking any pictures of my bald head, so I don’t have any good “before” pictures of the top of my head.
as I predicted nothing in the pics to say that Rapa is having an effect. Your hair is just normal for someone your age. Couple dark hairs here and there means nothing. If you really want thicker fuller hair, I suggest use Mino and finasteride. Clearly Rapa will not do much/anything for your hair.
You need to compare the photos to the previous ones. I monitor changes in my hair with a macro camera and compare changes in terms of colour change and new growth to doses of rapamycin.
I don’t need you to agree with me. The process of reversing balding is a hard process and it takes a long time.
Well, I hear you and I’m not disagreeing just for the sake of it, but you won’t reverse balding with Rapa no matter how high a dose. Again, I don’t know how you feel about minoxidil and finasteride (or if you’re taking them) but if you were to take them together, you’ll notice a big difference in 3-6 months. Unfortunately, Rapa won’t reverse your balding even if at times you get couple new hair here and there.
When I was balding myself, there were times that I’d feel I’m getting new hairs back (out of the blue) and that my hair line is improving etc… but they were all false alarms LOL and I was nowhere near as bad/bald as you. It is just normal process of balding, sometimes you get few new hairs, and then all of a sudden other hair just disappears.
At the core of the process is mitochondrial function. That drives the rest. Rapamycin can improve average mitochondrial function. I agree with the idea that dealing with DHT is also relevant.
I do know that intermittent fasting, extended fasting and caloric restriction can accelerate hair loss through telogen effluvium (and possibly graying of hair). mTOR inhibition does mimic a portion of fasting so it is mechanistically feasible.
If this is about my experience, I will clarify I still don’t have a ton of grey, and it’s significantly less than my friends have. I was just late to the party by not getting my first grey hair until I was over 50.
So, I don’t think rapa has caused any of it. I ‘should’ have a lot more than I have when turning 60 next month, I just know it didn’t prevent it.
John thinks it probably slowed it, and from what I see it doing to my health, I can believe it!
