I believe around 500 or so is when IGF1 peaks in bodybuilders using large amounts. However, some of them don’t even get their level north of 300 on a high dose so it’s really specific to a particular individual or there are other unknown factors in play. In any case, I really wouldn’t be worried about an IGF1 of 450 unless it was that way without HGH. The other labs look great and those matter a lot more.
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Exactly.
My Personal Physician’s attitude is this is what we were shooting for, obviously my stock of HGH is real and potent.
Costing me $100 per month… not $2,000 per month from a pharmacy prescription.
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This makes me wonder why my IGF is 251, on the high side, but free testosterone is 7.7 which is incredibly low while total testosterone is 579.
Would stopping whey protein supplementation help with this? I’m also going to start taking DHEA to try and sort all this out…
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Hmmm… interesting Chris.
DHEA might help.
I take it as part of my Thymus Regeneration… but due to low fat and regular weight training… probably not needed. But, definitely not hurting.
I was fearful of HGH possibly bringing on diabetes. But with insulin at 4 in my recent blood panel… not gonna happen. My physician was… you are better than good - golden!
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If I were you, I’d be happy about the 251 IGF1 at your age. I think purposely trying to lower it would bring more problems than it would solve. I wouldn’t touch it at all.
I don’t think whey would make a difference.
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Couldn’t resist asking AI to guess at Fahy’s new secret protocol… this is what Grok 4 guessed at:
"Based on recent updates from Dr. Greg Fahy’s work with the TRIIM and TRIIM-X trials, the protocol’s core regimen—recombinant human growth hormone (rhGH), dehydroepiandrosterone (DHEA), and metformin—has demonstrated partial thymus regeneration over 6–12 months, alongside epigenetic age reversal of ~1.5–2.5 years and improved immune markers like naive T-cell production. However, Fahy has hinted at self-testing a novel, undisclosed agent (described as safe, non-toxic, and potent) that reportedly accelerated epigenetic age reversal by ~6 years in just 90 days when combined with the existing cocktail, suggesting a focus on faster thymic reactivation and broader anti-aging effects.7fbcaefd4e7a While the exact identity remains secret (possibly tied to ongoing TRIIM-X optimizations like pathway modulators or in-house GH variants), here are three scientifically grounded suggestions for what could be added to accelerate thymus regeneration, drawn from complementary research on thymic biology. These build on the protocol’s GH-driven mechanism (which boosts IGF-1 to stimulate thymic epithelial cells) while addressing limitations like insulin resistance or slow epithelial proliferation.
- Keratinocyte Growth Factor (KGF/FGF7)
Rationale: KGF is a fibroblast growth factor that specifically targets thymic epithelial cells (the structural “scaffold” of the thymus), promoting their proliferation and differentiation to rebuild the organ’s architecture faster than GH alone. In mouse models of thymic involution, KGF administration restored thymic size and T-cell output by 2–3x within weeks, synergizing with GH by enhancing downstream IGF-1 signaling without exacerbating insulin issues (since metformin/DHEA already mitigate that).90b7e397cdd6 This could shorten TRIIM’s regeneration timeline from months to 1–3 months, as seen in preclinical combo therapies.
Dosing Suggestion: Low-dose subcutaneous injections (e.g., 1–5 μg/kg weekly), personalized via IGF-1 monitoring.
Potential Risks/Benefits: Minimal systemic effects (thymus-specific receptor); could amplify immune rejuvenation but requires monitoring for overgrowth. - A Growth Hormone Secretagogue (e.g., Ipamorelin or MK-677/Ibutamoren)
Rationale: These oral or injectable mimetics stimulate endogenous GH release via ghrelin receptor activation, raising IGF-1 levels more gradually and sustainably than rhGH injections—potentially speeding thymic regrowth by 50–100% in rodent studies while avoiding GH’s peak-dose side effects like joint pain or hyperglycemia (countered by the protocol’s DHEA/metformin).37a4784fcfe0 Fahy’s recent comments on optimizing IGF-1 with “much smaller” GH doses align with this, and community experiments (e.g., ipamorelin + CJC-1295) have shown faster naive T-cell increases in humans mimicking TRIIM.
Dosing Suggestion: MK-677 at 10–25 mg daily (oral, easier compliance) or ipamorelin 200–400 mcg nightly, titrated to IGF-1 targets of 170–200 ng/mL.
Potential Risks/Benefits: Better tolerability than rhGH; could enable cost-effective scaling but watch for mild appetite increase. - Interleukin-7 (IL-7) or an IL-7 Agonist
Rationale: IL-7 is a cytokine essential for thymic T-cell maturation and survival; supplementing it accelerates recent thymic emigrant (new T-cell) output by 2–4x in aged primates and humans post-thymectomy, complementing GH’s epithelial focus by “filling the pipeline” downstream. Combined with TRIIM, it could halve regeneration time by boosting overall thymopoiesis, as shown in HIV-related thymic recovery trials where IL-7 restored naive T-cells in 4–8 weeks.de505610a4d7
Dosing Suggestion: Recombinant IL-7 at 3–10 μg/kg weekly subcutaneously, with baseline lymphocyte monitoring.
Potential Risks/Benefits: Enhances vaccine efficacy and cancer surveillance; risk of transient lymphocytosis, but safe in short cycles.
These additions prioritize synergy with TRIIM’s foundation, targeting bottlenecks in epithelial expansion or T-cell export for quicker, more robust regeneration. Clinical validation (e.g., via TRIIM-X extensions) would be key, as Fahy’s team is reportedly exploring similar “pathway-shifting” tweaks for 2025 trials.6a8705 If more details emerge from Fahy’s updates, they could confirm or refine these."
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A quick thought on patents and AI. A patent application needs to be sufficiently “novel” to qualify. I wonder if ‘AI thinking of it’ when asked is enough to disqualify a new idea. And conversely I wonder whether AI generated patents will mean the system could become flooded.
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Thanks for posting. I am following the TRIIM protocol and just completed month 3. I am very eager to find out what his new ‘secret’ recipe is. Let’s hope it leaks out soon.
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